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Reliable AAV Capsid Titer determination


Recombinant Adeno-Associated Virus (rAAV) vectors are increasingly used for in vivo gene transfer to target inherited genetic diseases. Yet it is essential to carry out a reliable quantification of rAAV capsid titers to ensure a safe gene transfer to the target cell.

As the industry gold standard you can rely on PROGEN’s AAV ELISAs to consistently deliver dependable capsid titer determination. You can select from a portfolio of AAV titration ELISAs and Xpress ELISAs for the most commonly used AAV serotypes. These are based on PROGEN‘s exclusive portfolio of AAV particle antibodies.


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Your AAV ELISA Benefits


Easy-to-use:
all assays use a similar workflow for all AAV serotypes and do not require expensive equipment or special training. Includes single-break strips that can be used separately for different test runs. 

Quick: the ELISA Kits are ready to be shipped and easy to implement into all workflows. The Xpress ELISA Kits generate results in less than 2 hours without compromising performance.

Reliable: PROGEN‘s exclusive particle antibodies recognize native, non-denatured AAV capsids (full and empty) for the quantification of intact AAV particles. An industry gold standard with established success in clinical trials. 

Reproducible: an established and robust method that generates reproducible data (See Figure 1). Regular AAV ELISA users can easily achieve low inter- & intra-assay variance with a coefficient of variation (CV) below 10%. 

Accurate: AAV2 and AAV8 ELISAs are based on the ATCC international reference standard material and all remaining ELISAs (AAV1, 3, 5, 6, 9 and rh10) adhere to internal gold standards.

GMP-ready: can be validated for use in a GMP setting and adhere to FDA guidelines for the development of AAV gene therapies.  

 

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AAV Xpress ELISAs

Results in less than 2 hours

AAV Xpress ELISAs were created in response to the increasing need industry wide to get results faster and save time. The kit components have been adjusted to reduce the assay time by more than 50%. The Xpress ELISA kits have been developed based on the standard PROGEN ELISA kits, so they show the same accuracy and reproducibility. The only difference is you will be able to process a higher number of samples in less time. 

Both PROGEN's AAV ELISA and AAV ELISA Xpress Kits have reference standard status in gene therapy centers worldwide.

 

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What customers are saying


We’ve been using several kits every week and have had no trouble at all with them. We’ve been getting very good reproducibility and low variability between repeats, assays and users. Everyone is enjoying the speed of the assay and it has increased our throughput too.

Jennie Gullick, PhD, R&D Bioprocessing, Pall Corporation


Automating the AAV ELISA

 

Are you Team ELISA? But looking for a solution to shift from a hands-on assay to a fully automated assay? Using the DSX® Dynex® PROGEN has made significant steps towards fully automating our AAV ELISAs.

Download our latest poster to view a high-throughput protocol for the AAV9 ELISA using the DSX® Dynex®.

Key highlights:

  1. Insights on plate homogeneity, intra- and inter-assay variance as well as recovery obtained by the automated system

  2. Data comparison with the manual AAV ELISA

  3. Key takeaways from our automation journey

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Reliable and Reproducible Data

Watch our short 90 second video and find out how you can easily implement AAV ELISAs to reliably determine the capsid titer of your AAV preparation, with no expensive equipment required.

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