LNP Small Molecule Delivery Kit
- Easy to use
- High loading capacity
- Provides robust protection against degradation
- High stability in diverse biological media
- Narrow size distribution
- Facilitates biodistribution, enhancing pharmacokinetics and overall drug efficacy
- Minimal cytotoxicity in vitro and in vivo
- Available with fluorescence option, facilitating real-time tracking of drug-loaded nanoparticles in vitro
Product description
Quantity | 1 kit |
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Storage before reconstitution | -20ºC (avoid freeze/thaw cycles) |
Storage after reconstitution | Up to 48 hours at 2-8 ºC |
Intended use | Research use only |
Reconstitution | Formulate in Ethanol 96% per protocol. |
Application | Nanoparticle reagent kit for small molecule delivery |
Specificity | Small molecules |
Stability | Do not freeze Small Molecule Delivery LNPs. Do not heat up Small Molecule Delivery LNPs.
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Synonym | LNP |
Background
Nanoparticle reagent kit for small molecule delivery
Lipid Nanoparticle reagent kit for enhancing the solubility of hydrophobic and amphiphilic drugs, enabling their delivery in vitro and in vivo.
Applications
In vitro
- Labeling of live cells
- Intracellular delivery of therapeutic compounds
- Therapeutic evaluation
- Cytotoxicity studies
In vivo
- Biodistribution evaluation
- Therapeutic evaluation
About the LNP Small Molecule Delivery Kit
PROGENs LNP Small Molecule Delivery Lipid nanoparticles come as a dryed lipid emulsion, easy to formulate by bench-top addition of ethanol.
The Small Molecule Delivery LNPs prevent loaded drugs from external degradation and rapid clearance. They promote optimal biodistribution, high intracellular absorption and low toxicity, boosting their therapeutic effect. Moreover, the Small Molecule Delivery LNPs have shown efficacy in rodents and zebrafish models across various administration methods.
The composition and molar ratios of PROGENs LNP Small Molecule Delivery Kit is optimized for associating and delivering hydrophobic and amphiphilic small molecules and can be used to efficiently deliver the drug of interest to specific cell lines and animal models. Different formulation protocols should be followed based on the nature of your molecule of interest.
PROGENs LNP Small Molecule Delivery Kit has been validated with molecules that possess various molecular weights (from 297 to 974 g/mol), and n-octanol/water partition coefficient (Log POW from –0.4 to 8.5). If your molecule exceeds the mentioned properties and conditions, please enquire for a customized solution. Additionally, PROGEN offers customized solutions for surface-decorated nanoparticles with tissue-specific ligands, enabling targeted delivery.
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FAQs
BUFFER SOLUTION | CONCENTRATION |
Ultrapure water | N/A |
PBS | 2-50 mM |
NaCl | 150 mM |
HEPES | 10-25 mM |
DPBS | 1X |