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AAV8 Titration ELISA

Unique microtiter plate enzyme immunoassay for the quantitation of intact AAV8 wt virions, AAV8 recombinant virions or assembled and intact empty capsids of human Adeno-associated Virus 8. The capture-antibody detects a conformational epitope not present on unassembled capsid proteins.


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Cat. No.: PRAAV8
Quantity:  96 tests

Delivery Time: usually 1-7 working days

€499.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Details 2 Kit Control/Standard:AAV8 empty capsids; lyophilized
Form supplied Reagent kit, 12 x 8-well strips
Function RUO

Background

Details

Unique microtiter plate enzyme immunoassay for the quantitation of intact AAV8 wt virions, AAV8 recombinant virions or assembled and intact empty capsids of human Adeno-associated Virus 8. The capture-antibody detects a conformational epitope not present on unassembled capsid proteins.

Reference

Reference

Sonntag F, Köther K, Schmidt K, Weghofer M, Raupp C, Nieto K, Kuck A, Gerlach B, Böttcher B, Müller OJ, Lux K, Hörer M, Kleinschmidt JA. The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno- Associated Virus Serotypes. J Virol (2011) 85(23):12686- 12697. DOI: 10.1128/JVI.05359-11. PMC: 3209379

Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M: Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. J Virol (2012) 86(15):7739. DOI: 10.1128/JVI.00218-12.Pubmed: 22593150

PROGEN's AAV-8 Titration ELISA was used for the validation study of AAV-8 Reference Standart Material: 

Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira M R, Auricchio A, Bucher S, Chtarto A, Reed Clark K, Darmon C, Doria M, Fountain W, Gao G, Gao K, Giacca M, Kleinschmidt J, Leuchs B, Melas  C, Mizukami H, Müller M, Noordman Y, Bockstael O, Ozawa K, Pythoud C, Sumaroka M, Surosky R, Tenenbaum L, van der Linden I, Weins B, Fraser Wright J, Zhang X, Zentilin R, Bosch F, Snyder R O, Moullier P: Manufacturing and Characterization of a Recombinant Adeno-Associated Virus Type 8 Reference Standard Material. Human Gene Therapy 25:977-987 (November 2014). DOI: 10.1089/hum.2014.057

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