Epitope mapped
Disease related

anti-Butyrophilin mouse monoclonal, 102.43, supernatant

Cat. No. 651153

Available, delivery time 1-7 days

€202.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with bovine and human
  • Isotype: IgG2a kappa
Product description
Quantity 5 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG2a kappa
Conjugate Unconjugated
Application IHC, WB
Purification Hybridoma cell culture supernatant
Reactivity Bovine, Human
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone 102.43
Immunogen Butyrophilin purified from bovine milk fat globule membrane
Formulation Contains 0.09% sodium azide
UniprotID P18892 (Bovine),Q13410 (Human)
Synonym Butyrophilin subfamily 1 member A1, BT, BTN1A1, BTN
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen Ready-to-use
Western Blot (WB) Assay dependent
Background

The mab reacts specifically with butyrophilin, a unique 67 kD polypeptide present in lactating mammary gland epithelium and in the milk fat globule membrane (MFGM).
No cross-reaction with other MFGM proteins. The epitope has been localized on the N-terminal extracellular part of the protein, close to the transmembrane region.
Butyrophilins have recently been described as a new family of immunoregulators, similar to the co-stimulatory and co-inhibitory family of B7 molecules (Arnett & Viney, 2014).

Polypeptide reacting:Butyrophilin, 67 kD polypeptide; present in the apical membrane of lactating mammary epithelium and in MFGM.

Reactivity on cultured cell lines: Transfected cell line BMGE with butyrophilin cDNA.

Positive control: Milk fat globule membrane (MFGM).

Arnett HA & Viney JL: Immune modulation by butyrophilins. Nature Review Immunology 14, 559-569 (2014)

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