anti-Keratin K80 guinea pig polyclonal, serum

Cat. No. GP-K80

Available, delivery time 1-7 days

€256.00*

Key Features
  • Guinea pig polyclonal
  • Suitable for IHC and WB
  • Reacts with human and mouse
Product description
Quantity 100 µl
Antibody Type Polyclonal
Host Guinea pig
Conjugate Unconjugated
Application IHC, WB
Purification Stabilized antiserum
Reactivity Human, Mouse
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Immunogen Synthetic peptide from human K80: IKI TEM SEK YFS QE-C
Formulation Contains 0.09% sodium azide and 0.5% BSA
UniprotID Q6KB66 (Human), Q0VBK2 (Mouse)
Synonym Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20
Note Centrifuge prior to opening
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:500
Western Blot (WB) Assay dependent
Background
K80 is found in virtually all types of epithelia (stratified keratinizing-/ non-keratinizing-, hard-keratinizing- as well as non-stratified tissues, and cell cultures thereof). Throughout, K80 expression is related to advanced tissue or cell differentiation. However, instead of being part of the cytoplasmic IF network, K80 containing IFs are located at the cell margins close to the desmosomal plaques, where they are tightly interlaced with the cytoplasmic IF bundles abutting there. In contrast, in cells entering terminal differentiation, K80 adopts the "conventional" cytoplasmic distribution. In addition, KRT80 mRNA is subject to alternative splicing resulting in fully functional splice variant K80.1.
References/Publications (1)
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