anti-LDL Receptor rabbit polyclonal, Biotin Conjugate
- Biotin conjugate
- Rabbit polyclonal
- Suitable for FACS and Receptor Binding Assays
- Reacts with human
|Application||FACS, Receptor binding assay|
|Intended use||Research use only|
|Immunogen||Specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the human LDL receptor extracellular domain (epitope between residues nos. 184-195, the linker region between repeats 4 and 5)|
|Formulation||PBS pH 7.4 with penicillin/streptomycin|
|UniprotID||P01130 (Human), P01131 (Bovine), P35951 (Mouse), P35952 (Rat)|
|Synonym||Low-density lipoprotein receptor, LDL receptor, LDLR|
|Note||Centrifuge prior to opening|
|Tested applications||Tested dilutions|
|Flow Cytometry (FACS)||1:10|
|Receptor Binding Assays||Assay dependent|
The LDL receptor (160 kDa mature or glycosylated receptor; 120 kDa precursor or unglycosylated receptor) plays a key role in cellular cholesterol homeostasis.
The antibody to LDLR reacts specifically with human LDLR and is suitable for use in flow cytometry and immunoblotting. The antibody does not inhibit binding of LDL.
In immunoblotting, the antibody recognizes the 160 kDa band of LDLR and a 120 kDa band of the LDLR precursor from fibroblasts, hepatocytes, and monocytic cells cultured in the presence of lipoprotein-deficient serum.
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