anti-MALT1 mouse monoclonal, EBS-T-007, purified

Cat. No. 691674

Available, delivery time 1-7 days

€340.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC and WB
  • Reacts with human
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application IHC, WB
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone EBS-T-007
Immunogen Human MALT1 recombinant protein
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID Q9UDY8 (Human)
Synonym Mucosa-associated lymphoid tissue lymphoma translocation protein 1, EC 3.4.22.-, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml; microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)
Background

EBS-T-007 reacts with paracaspase MALT1, crucial for B- and T-cell activation/proliferation and activation of transcription factor NF-kappaB. It has a N-terminal death domain, two central immunoglobulin-like domains involved in the binding to the B-cell lymphoma 10 (BCL10) protein and a caspase-like domain. MALT1 and BCL10 can both be found translocated in MALT lymphoma. In such cases either BCL10 or MALT1 or both are highly expressed, depending on the site of translocation. Normal cells and MALT lymphomas lacking translocations exhibit much lower levels of expression.

Positive control: HepG2 cells or lymphoma.

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