anti-MUC5AC/M1 mouse monoclonal, 58M1, purified

Cat. No. 691521

Available, delivery time 1-7 days

€340.00*

Key Features
  • Mouse monoclonal
  • Suitable for ELISA, IHC and WB
  • Reacts with cat, human, monkey and mouse
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application ELISA, IHC, WB
Purification Affinity chromatography
Reactivity Cat, Human, Monkey, Mouse
No reactivity Rat
Storage 2-8°C
Intended use Research use only
Clone 58M1
Immunogen Mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification) from an ALeb patient.
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID P98088 (Human), E9PWB6 (Mouse)
Synonym Mucin-5AC, MUC-5AC, Gastric mucin, Major airway glycoprotein, Mucin-5 subtype AC, Tracheobronchial, Tracheobronchial mucin, TBM, MUC5AC, MUC5
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml; microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
ELISA Assay dependent
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)
Background

58M1 recognizes the peptide core of gastric mucin M1 (now: MUC5AC), and more specifically with the 'e' epitope amongst the a, b, c, d, e, f, g and h protein core epitopes defined by Bara for M1. MUC5AC is present in primary ovarian mucinous cancer and gastric cancer, but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.

Positive control: stomach, gastric cancer.

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