anti-Proliferation Marker mouse monoclonal, IPO-38, purified

Cat. No. 691701

Available, delivery time 1-7 days


Key Features
  • Mouse monoclonal
  • Suitable for ELISA, IHC, IP and WB
  • Reacts with human, mouse and rat
  • Isotype: IgM kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgM kappa
Conjugate Unconjugated
Application ELISA, IHC, IP, WB
Purification Affinity chromatography
Reactivity Human, Mouse, Rat
Storage 2-8°C
Intended use Research use only
Clone IPO-38
Immunogen Spleen cells of a patient with hairy cell leukemia
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
UniprotID P46013 (Human), E9PVX6 (Mouse), Q5RJM0 (Rat)
Synonym Proliferation marker protein Ki-67, Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, Antigen Ki67, MKI67
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml; microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
ELISA Assay dependent
Immunoprecipitation (IP) Assay dependent
Western Blot (WB) 1:50-1:100 (1-2 µg/ml)

IPO-38 reacts with a 12-14 kDa protein, as found in Western blots of Raji cells, and appears in the mitotic cycle earlier than Ki-67. Lymphocytes, induced to early G1 phase by 12h exposure to PHA, will become positive while non-stimulated lymphocytes remain negative. Mononuclear cells and granulocytes of healthy donors are negative, while various forms of leukemia and lymphoma including Hodgkin’s disease are positive for IPO-38, as are many solid tumors such as some breast, gastric and colonic cancers for which it may serve as tumor progression marker.

Positive control: Raji cells.

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