anti-SALL4 mouse monoclonal, IHC659, purified
- Mouse monoclonal
- Suitable for IHC
- Reacts with human
- Isotype: IgG1
|Intended use||Research use only|
|Immunogen||Recombinant Human SALL4|
|Formulation||Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide|
|Synonym||Sal-like protein 4, Zinc finger protein 797, Zinc finger protein SALL4, SALL4, ZNF797
|Tested applications||Tested dilutions|
|Immunohistochemistry (IHC) - paraffin||1:50-1:200 (microwave treatment recommended)|
Sal-Like Protein 4 (SALL4) is a zinc finger transcription factor found in germ cells and human blood progenitor cells, with functional involvement in modulating Oct-4 to maintain embryonic stem cell pluripotency. SALL4 is a useful marker for acute myeloid leukemia, B-cell acute lymphocytic leukemia, intratubular germ cell neoplasia, seminomas/dysgerminomas, and yolk sac tumours (both pediatric and postpubertal). Anti-SALL4 is used to detect embryonal carcinomas, hepatocellular carcinoma (HCC), gliomas, ovarian primitive germcell tumours, choriocarcinomas, spermatogonia, teratoma, gastric cancer, breast cancer, and lung cancer. Expression of SALL4 is often associated with poor prognosis in HCC, and with metastasis in endometrial cancer, colorectal carcinoma, and esophageal squamous cell carcinoma.
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