anti-Substance P (aa 4-11) rabbit polyclonal, serum
- Rabbit polyclonal
- Suitable for IHC on frozen and paraffin sections
- Reacts with human and rat
Product description
| Quantity | 50 µl (lyoph.) |
|---|---|
| Antibody Type | Polyclonal |
| Host | Rabbit |
| Conjugate | Unconjugated |
| Application | IHC |
| Purification | Undiluted antiserum |
| Reactivity | Human, Rat |
| Storage before reconstitution | 2-8°C until indicated expiry date |
| Storage after reconstitution | Up to 3 months at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles |
| Intended use | Research use only |
| Immunogen | Synthetic Substance P 4-11, conjugated to thyroglobulin using CDI |
| Formulation | Lyophilized; reconstitute in 100 µl dist. water |
| UniprotID | P25103 (Human), P06767 (Rat), P14600 (Rat) |
| Synonym | Substance-P receptor, SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1, TACR1, NK1R, TAC1R |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunohistochemistry (IHC) - frozen | 1:400-1:800 |
| Immunohistochemistry (IHC) - paraffin | 1:400-1:800 (microwave treatment recommended) |
Background
Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, broncho-constriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Absorption with 10-100 ug SP 1-4 per ml diluted antiserum abolishes the staining.
Positive control: frozen sections of rat colon.
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FAQs
The concentration of purified antibodies is mentioned on the datasheet.
For prediluted antibodies the concentration may vary from lot to lot. The concentration of these antibodies is not mentioned on the datasheet and can be requested at support@progen.com.
The supernatant format contains FCS proteins from cell culture medium supplemented with FCS.
The serum antibodies contain other proteins present in serum.
Most of our liquid antibodies and reconstituted lyophilized antibodies may be stored for short term storage (up to 3 month) at 2-8°C. For long term storage we recommend to store the antibody at -20°C in aliquots. Please avoid freeze and thaw cycles.
Most of our conjugated antibodies should be stored at 2-8°C.
The individual storage conditions are mentioned on the datasheet.
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