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Dot blot with different AAV serotypes and mouse monoclonal anti-AAV1 antibody, clone ADK1a (Courtesy of Regina Heilbronn, Charité Universitätsmedizin Berlin, Mietzsch et al. Hum Gene Ther. 2014 Mar 1; 25(3):212-222) Zoom

Dot blot with different AAV serotypes and mouse monoclonal anti-AAV1 antibody, clone ADK1a (Courtesy of Regina Heilbronn, Charité Universitätsmedizin Berlin, Mietzsch et al. Hum Gene Ther. 2014 Mar 1; 25(3):212-222)

anti-AAV1 (intact particle) mouse monoclonal, ADK1a, lyophilized, purified

Specifically detects AAV1 intact virus particles, both empty and full capsids. ADK1a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not suitable for Immunoblotting. In immunofluorescence and dot plot analysis, a week cross-reactivity was observed with AAV6 and AAV12. No reaction with other AAV types.


The ADK1a antibody is used as capture and detection antibody in the AAV1 Titration ELISA (PRAAV1).

Cat. No.: 610150
Quantity:  50 µg

Delivery Time: usually 1-7 working days

$427.00
Excl. VAT, excl. Shipping Cost

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Specifications

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anti-AAV1 (intact particle) mouse monoclonal, ADK1a

lyophilized, purified, sample 10 µg
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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2a lambda
Clone ADK1a
Immunogen AAV1 capsids
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity AAV1, AAV6, AAV12

Applications

Tested applications Tested dilutions
Affinity Chromatography assay dependent
Dot Blot assay dependent (non-denaturing conditions)
ELISA assay dependent
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:20
Immunoprecipitation (IP) 1:5
Neutralization Assay assay dependent

Background

Details

For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK1a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins. The antibody cannot be used for immunoblotting.

Limited Use Label License: Research Use Only
Product is exclusively licensed to PROGEN Biotechnik GmbH. The use of these products for the development, manufacturing and sale of secondary products/derivatives which are based on the purchased products and/or which include the purchased product require a royalty based sub-license agreement.

Reference

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