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Product description
| Host | rabbit |
|---|---|
| Antibody Type | polyclonal |
| Immunogen | Bombesin (#7113, Peninsula), conjugated to BSA |
| Purification | undiluted antiserum |
| Conjugate | unconjugated |
| Formulation | lyophilized; reconstitute in 100 µl dist. water |
| Storage | short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles |
| No. of experiments | ≤ 6000 (IHC, 50 µl/slide) |
| Intended use | Research use only |
| Tested species reactivity | chicken, human, rat |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunohistochemistry (IHC) - frozen | 1:800 - 1:3,000 |
| Immunohistochemistry (IHC) - paraffin | 1:800 - 1:3,000 (microwave treatment recommended) |
Background
Details
Bombesin is an amphibian peptide and the mammalian counterpart is referred to as Gastrin Releasing Peptide (GRP). Bombesin/GRP is widely distributed in the brain, in peripheral nerves (particularly numerous in the gut) and in endocrine cells of some sub-mammalian species, e.g. in the oxyntic mucosa of birds. The peptide stimulates secretion from endocrine and exocrine cells and intestinal smooth muscle activity. Bombesin/GRP occurs frequently in the bronchial carcinoids.
Absorption with 10-100 µg bombesin and GRP per ml diluted antiserum abolishes the staining.
Positive control: Formalin-fixed paraffin and frozen sections of rat or chicken stomach.
Reference
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