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anti-Butyrophilin guinea pig polyclonal, serum

The antiserum reacts specifically with butyrophilin, a unique 67 kD polypeptide present only in lactating mammary gland epithelium and in the milk fat globule membrane (MFGM).
Cat. No.: GP153
Quantity:  100 µL

Delivery Time: usually 1-7 working days

€266.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Host guinea pig
Antibody Type polyclonal
Immunogen Butyrophilin purified from bovine milk fat globule membrane
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity bovine, human, mouse, rat

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:100 - 1:200
Immunohistochemistry (IHC) - paraffin 1:100 – 1:200 (microwave treatment recommended)
Western Blot (WB) 1:2,000

Background

Details

The antiserum reacts specifically with butyrophilin, a unique 67 kD polypeptide present only in lactating mammary gland epithelium and in the milk fat globule membrane (MFGM). No cross-reaction with other MFGM proteins.
Butyrophilins have recently been described as a new family of immunoregulators, similar to the co-stimulatory and co-inhibitory family of B7 molecules.

Reference

Reference

 

Franke WW, Heid HW, Grund C, Winter S, Freudenstein C, Schmid E, Jarasch ED, Keenan TW: Antibodies to the major insoluble milk fat globule membrane-associated protein. Specific location in apical regions of lactating epithelial cells. J Cell Biol 89, 485-494 (1981)

 

Ogg SL, WeldonAK, Dobbie L, Smith AJH, Mather IH: Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci USA 101, 10084-10089 (2004)

 

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