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anti-Cadherin 11 mouse monoclonal, 16A, supernatant

Cadherin 11 is a potential marker for aggressive, invasive tumor subsets.
Cat. No.: 18319
Quantity:  1 mL
No. of experiments:  ≤ 20 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

$229.00
Excl. VAT, excl. Shipping Cost

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Specifications

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone 16A
Immunogen GST fusion protein of part of the extracellular domain of cadherin 1 (OB-Cadherin)
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 20 (IHC, 50 µl/slide)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity human

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) ready-to-use
Immunohistochemistry (IHC) - frozen ready-to-use (paraformaldehyde fixation and preincubation of sections with 0.2% Triton X-100 in PBS, supplemented with 0.1 mM CaCl2 and 0.1 mM MgCl2 recommended)

Background

Details

The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12.
Cadherin-11 (OB-cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of cadherin-11 has been found in brain, spinal cord, bone marrow and bone cells, and it is regulated in human endometrial glandular epithelial and stromal cells. Recently, cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested (but not in non-invasive cell lines), suggesting cadherin-11 as a potential marker for aggressive, invasive tumor subsets.

Positive control: PC-3 cell line (human prostate cell line)

Reference

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