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anti-Calcitonin Gene Related Peptide (human) guinea pig polyclonal, serum

CGRP is present in the C-cells of the thyroid and in nerves in the brain and periphery. Medullary carcinomas of the thyroid show large amounts of CGRP. The antiserum cross-reacts with amylin (APP).
Cat. No.: 16010
Quantity:  50 µL

Delivery Time: usually 1-7 working days

$514.00
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Specifications

Product description

Host guinea pig
Antibody Type polyclonal
Immunogen Synthetic human calcitonin gene-related peptide (CGRP; #6009, Peninsula)
Purification undiluted antiserum
Conjugate unconjugated
Formulation lyophilized; reconstitute in 100 µl dist. water
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity human, rat

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen 1:1,000 - 1:2,000
Immunohistochemistry (IHC) - paraffin 1:1,000 - 1:2,000 (microwave treatment recommended)

Background

Details

The CGRP-sequence was predicted from the corresponding mRNA. CGRP is present in the C-cells of the thyroid and in nerves, in both brain and periphery, particularly within the sensory system. CGRP is a potent vasodilator, probably involved in neurogenic inflammation. Medullary carcinomas of the thyroid contain large amounts of CGRP. Absorption with 10 – 100 µg CGRP per ml diluted antiserum abolishes the staining while calcitonin, does not. Cross-reacts with amylin (IAPP).
Positive control: Stefanini-fixed frozen sections of rat colon.

Reference

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