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Product description
| Host | mouse |
|---|---|
| Antibody Type | monoclonal |
| Isotype | IgG1 |
| Clone | 242G3 |
| Immunogen | purified human complement C1q |
| Purification | protein A affinity chromatography |
| Conjugate | unconjugated |
| Formulation | lyophilized; reconstitute in 1 mL dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4) |
| Storage | short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles |
| UniprotID | P02745 |
| No. of experiments | ≤ 20 (WB, 5 ml reaction volume) |
| Intended use | Research use only |
| Tested species reactivity | human |
Applications
| Tested applications | Tested dilutions |
|---|---|
| ELISA | assay dependent |
| Western Blot (WB) | 1:100 |
Background
Details
Detection of C1q in serum, in serum-C1 and within immune complexes; inhibits hemolytic activity of C1 by binding to C1q in the liquid phase (antibody concentration necessary to inhibit 50% of hemolytic activity in the fluid phase is 0.85 µg/ml). With C1 bound to immune complexes a dose dependent increase of C1 activity was observed at antibody concentrations of 1.5 µg/ml. Useful for detection of C1q-bearing immune complexes in patients with rheumatic disorders.
Polypeptide reacting: C-chain of complement C1q (25 kD in SDS-PAGE)
Reference
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