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anti-Complement C1q mouse monoclonal, 242G3, supernatant

The antibody reacts with C1q in serum, in serum-C1 and within immune complexes. Useful for detection of C1q-bearing immune complexes in patients with rheumatic disorders.
Cat. No.: 651136
Quantity:  5 mL

Delivery Time: usually 1-7 working days

€160.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2b
Clone 242G3
Immunogen purified human complement C1q
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity human

Applications

Tested applications Tested dilutions
ELISA assay dependent
Western Blot (WB) 1:10 - 1:50

Background

Details

Detection of C1q in serum, in serum-C1 and within immune complexes; inhibits hemolytic activity of C1 by binding to C1q in the liquid phase (antibody concentration necessary to inhibit 50% of hemolytic activity in the fluid phase is 0.85 µg/ml). With C1 bound to immune complexes a dose dependent increase of C1 activity was observed at antibody concentrations of 1.5 µg/ml (Heinz et al. 1984). Useful for detection of C1q-bearing immune complexes in patients with rheumatic disorders.

Polypeptide reacting: C-chain of complement C1q (approx. 25 kD in SDS-PAGE).

Heinz HP, Burger R, Golan DG, Loos M: Activation of the first component of complement, C1, by a monoclonal antibody recognizing the C chain of C1q. J Immunology 132, 804-808 (1984).

Reference

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