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  • anti-delta Catenin mouse monoclonal, J19, supernatant

delta Catenin staining on human cerebral cortex (courtesy of The Human Protein Atlas, www.proteinatlas.org, Thul PJ et al, 2017. A subcellular map of the human proteome. Science) Zoom

delta Catenin staining on human cerebral cortex (courtesy of The Human Protein Atlas, www.proteinatlas.org, Thul PJ et al, 2017. A subcellular map of the human proteome. Science)

anti-delta Catenin mouse monoclonal, J19, supernatant

The monoclonal anti-delta Catenin antibody reacts specifically with neurojungin (delta-catenin), a unique 140 kD polypeptide of the plakoglobin / armadillo protein family. Neurojungin is present in adhering type junctions in the nervous system and is primarily expressed in the brain.
Cat. No.: 651152
Quantity:  5 mL

Delivery Time: usually 1-7 working days

$245.00
Excl. 19% Tax, excl. Shipping Cost

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Specifications

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone J19
Immunogen Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity bovine, human, mouse, rat, zebrafish

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen ready-to-use
Immunohistochemistry (IHC) - paraffin ready-to-use (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

The mab reacts specifically with neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Delta-catenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimer’s disease. No cross-reaction with other members of the armadillo / plakoglobin protein family.
Polypeptide reacting: Neurojungin (delta-catenin), 160 kD polypeptide; in endothelia from blood vessels the antibody is positive with a 300 kD polypeptide.
Reactivity on cultured cell lines: Murine cell line A1B2, A431 stably transfected with neurojungin cDNA.
Positive control: Murine brain, retina.

Reference

Reference

PublicationSpeciesApplication
Paffenholz, R., Kuhn, C., Grund, C., Stehr, S. & Franke, W. W. The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. Exp. Cell Res. 250, 452–64 (1999). mouse, bovine WB, IHC (frozen), IEM

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