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Product description
| Host | mouse |
|---|---|
| Antibody Type | monoclonal |
| Isotype | IgG1 |
| Clone | J19 |
| Immunogen | Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH |
| Purification | hybridoma cell culture supernatant |
| Conjugate | unconjugated |
| Formulation | contains 0.09% sodium azide |
| Storage | short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles |
| Intended use | Research use only |
| Tested species reactivity | bovine, human, mouse, rat, zebrafish |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunohistochemistry (IHC) - frozen | ready-to-use |
| Immunohistochemistry (IHC) - paraffin | ready-to-use (microwave treatment recommended) |
| Western Blot (WB) | assay dependent |
Background
Details
The mab reacts specifically with neurojungin (delta-catenin,a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Delta-catenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimer’s disease. No cross-reaction with other members of the armadillo / plakoglobin protein family.
Polypeptide reacting: Neurojungin (delta-catenin), 160 kD polypeptide; in endothelia from blood vessels the antibody is positive with a 300 kD polypeptide.
Reactivity on cultured cell lines: Murine cell line A1B2, A431 stably transfected with neurojungin cDNA.
Positive control: Murine brain, retina.
Reference
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IHC-IF
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