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IHC of human skin (© PROGEN in cooperation with Uniklinik Heidelberg, Dr. Jochen Heß) Zoom

IHC of human skin (© PROGEN in cooperation with Uniklinik Heidelberg, Dr. Jochen Heß)

anti-Desmoglein 1/2 mouse monoclonal, DG 3.10, lyophilized, purified

DG 3.10 anti-desmoglein 1/2 antibody recognizes desmoglein 1 + 2 in desmosome-bearing cells; does not react with cells containing plaque-bearing junctions of non-desmosomal type.

highly_published external_validation
Cat. No.: 61002
Quantity:  50 µg

Delivery Time: usually 1-7 working days

$318.00
Excl. 19% Tax, excl. Shipping Cost

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Specifications

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anti-Desmoglein 1/2 mouse monoclonal, DG 3.10

purified, sample (ready-to-use) 600 µl (ready-to-use)
$65.00
Excl. 19% Tax, excl. Shipping Cost

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone DG 3.10
Immunogen "Band 3" polypeptide of isolated desmosomes from bovine muzzle epidermis
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 mL dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity bovine, human, rat

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen 1:10 - 1:100
Immunohistochemistry (IHC) - paraffin 1:10 - 1:100 (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

DG 3.10 recognizes desmoglein 1 + 2 (desmosome-specific cadherins) in desmosome-bearing cells; does not react with cells containing plaque-bearing junctions of non-desmosomal type. Tumors specifically detected: all epithelium-derived tumors, notably carcinomas, and meningiomas. Polypeptide reacting: Mr 165 000 Desmoglein, "band 3" polypeptide of the desmosomal complex. Epitope recognized has been localized at the repeating unit domain ("RUD") of the cytoplasmic C-terminal part of the polypeptide.

Reactivity on cultured cell lines: A-431, MDBK.

Reference

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