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anti-Desmoglein 1 mouse monoclonal, Dsg1-P124, supernatant

The monoclonal anti-desmoglein 1 antibody stains basal and lower suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. Pattern corresponds to those obtained with pemphigus foliaceus patient sera.
Cat. No.: 651111
Quantity:  5 mL

Delivery Time: usually 1-7 working days

€196.00
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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2a
Clone Dsg1-P124
Immunogen recombinant human Desmoglein 1 (extracellular part EII, EIII and EIV)
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
UniprotID Q02413
Tested species reactivity human

Applications

Immunohistochemistry (IHC) - frozen ready-to-use (preincubation (directly after fixation) with 0.05 - 0.2% Triton X-100 for 5 – 10 min, depending on tissue type, recommended)
Immunohistochemistry (IHC) - paraffin ready-to-use (preincubation with 0.001% trypsin and addition of 2% milk powder to the incubation media and microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

In immunoblots of cytoskeletal preparations from human skin the antibody reacts specifically with a 160 kD polypeptide typical for Desmoglein 1. In immunolocalization studies the mab shows typical staining of suprabasal layers of the epidermis and special regions of fetal anagen hair follicles. The staining pattern observed corresponds to those obtained with pemphigus foliaceus patient sera. Cross-reaction with Desmogleins 2 and 3 was not detected.

Reference

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