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anti-Desmoglein 1 mouse monoclonal, Dsg1-P23, supernatant concentrate

In immunoblots of cytoskeletal preparations from human skin the antibody reacts specifically with a 160 kD polypeptide typical for Desmoglein 1. In immunolocalisation studies the monoclonal desmoglein 1 antibody shows typical staining of suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. The staining pattern observed corresponds to those obtained with pemphigus foliaceus patient sera.
Cat. No.: 652110
Quantity:  0.5 mL

Delivery Time: usually 1-7 working days

€371.00
Excl. 0% Tax, excl. Shipping Cost

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Cat. No. Product Name Format Quantity Price
651110

anti-Desmoglein 1 mouse monoclonal, Dsg1-P23

supernatant 5 mL
€211.00
Excl. 19% Tax, excl. Shipping Cost

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone Dsg1-P23
Immunogen recombinant human polypeptide Desmoglein 1 (extra-cellular part EII, EIII and EIV)
Purification hybridoma cell culture supernatant concentrate
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity human

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:1,000 (for better resolution preincubation (directly after fixation) with 0.05 - 0.2% Triton X-100 for 5 - 10 min, depending on tissue type, is recommended)
Immunohistochemistry (IHC) - paraffin 1:1,000 (microwave treatment recommended; for better staining preincubation with 0.001% trypsin and addition of 2% milk powder to the incubation media is recommended)
Western Blot (WB) assay dependent

Background

Details

In immunoblots of cytoskeletal preparations from human skin the antibody reacts specifically with a 160 kD polypeptide typical for Desmoglein 1. In immunolocalization studies the mab shows typical staining of suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. The staining pattern observed corresponds to those obtained with pemphigus foliaceus patient sera.
Cross-reaction with Desmogleins 2 and 3 was not detected.

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