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anti-Desmoplakin 1/2 mouse monoclonal, DP 1 + 2-2.15, lyophilized, purified

The anti-desmoplakin 1/2 antibody decorates desmoplakin 1 and 2 in desmosomal complexes. The anti-desmoplakin 1/2 antibody is useful for staining of primary and metastatic carcinoma.
Cat. No.: 61003
Quantity:  50 µg

Delivery Time: usually 1-7 working days

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone DP1 + 2-2.15
Immunogen bovine desmoplakin 1&2
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity bovine, chicken, human, mouse, rat


Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen 1:10
Western Blot (WB) assay dependent



DP1&2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: Primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000)

Tested cultured cell lines: Several human carcinoma cell lines: MCF-7, A-431; rat MH1C1 cell line; bovine cells: MDBK, BMGE



  1. Bosch, F. X., Andl, C., Abel, U. & Kartenbeck, J. E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: A comparison of E-cadherin with desmosomal components. Int. J. Cancer 114, 779–790 (2005).
  2. Hatzfeld, M., Haffner, C., Schulze, K. & Vinzens, U. The Function of Plakophilin 1 in Desmosome Assembly and Actin Filament Organization. J. Cell Biol. 149, 209–222 (2000).
  3. Schmelz, M. & Franke, W. W. Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: the syndesmos connecting retothelial cells of lymph nodes. Eur. J. Cell Biol. 61, 274–89 (1993).
  4. Owaribe, K., Nishizawa, Y. & Franke, W. W. Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells. Exp. Cell Res. 192, 622–30 (1991).
  5. Moll, I. & Moll, R. Comparative cytokeratin analysis of sweat gland ducts and eccrine poromas. Arch. Dermatol. Res. 283, 300–9 (1991).
  6. Owaribe, K. et al. The hemidesmosomal plaque. I. Characterization of a major constituent protein as a differentiation marker for certain forms of epithelia. Differentiation. 45, 207–20 (1990).
  7. Koch, P. J. et al. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur. J. Cell Biol. 53, 1–12 (1990).
  8. Dockhorn-Dworniczak, B. et al. Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas. Differentiation. 35, 53–71 (1987).
  9. Moll, R., Cowin, P., Kapprell, H. P. & Franke, W. W. Desmosomal proteins: new markers for identification and classification of tumors. Lab. Invest. 54, 4–25 (1986).
  10. Cowln, P., Kapprell, H.-P. & Franke, W. W. The Complement of Desmosomal Plaque Proteins in Different Cell Types. J. Cell Biol. 101, 1442–1454 (1985).
  11. Franke, W. W. et al. Immunocytochemical identification of epithelium-derived human tumors with antibodies to desmosomal plaque proteins (cell junctions/cytoskeleton/tumor diagnosis/carcinoma). Proc. Natl. Acad. Sci. USA 80, 543–547 (1983).

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