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Product description
Host | mouse |
---|---|
Antibody Type | monoclonal |
Isotype | IgG2a |
Clone | MH104 |
Immunogen | human factor VIII antigen |
Purification | protein A affinity chromatography |
Conjugate | unconjugated |
Formulation | lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4) |
Storage | short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles |
Intended use | Research use only |
Tested species reactivity | human |
Applications
Tested applications | Tested dilutions |
---|---|
ELISA | 1:5,000 |
Immunohistochemistry (IHC) - frozen | assay dependent |
Western Blot (WB) | assay dependent |
Background
Details
MH104 is specific for human factor VIIIc, a 300 kD protein present in plasma in a complex with von Willebrandt factor. Involved in the clotting cascade (activated by thrombin) by forming a complex with factor IXa, calcium, and phospholipids.
Polypeptide reacting: Factor VIIIc protein (epitope localization: intact 83 kD light chain).
Disorders specifically detected: Elevated levels of factor VIII have been associated with acute and chronic liver diseases, vascular disorders, diabetes and with acute-phase reactions.
Reference
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