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Product description
| Host | mouse |
|---|---|
| Antibody Type | monoclonal |
| Isotype | IgG2a |
| Clone | MH104 |
| Immunogen | human factor VIII antigen |
| Purification | protein A affinity chromatography |
| Conjugate | unconjugated |
| Formulation | lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4) |
| Storage | short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles |
| Intended use | Research use only |
| Tested species reactivity | human |
Applications
| Tested applications | Tested dilutions |
|---|---|
| ELISA | 1:5,000 |
| Immunohistochemistry (IHC) - frozen | assay dependent |
| Western Blot (WB) | assay dependent |
Background
Details
MH104 is specific for human factor VIIIc, a 300 kD protein present in plasma in a complex with von Willebrandt factor. Involved in the clotting cascade (activated by thrombin) by forming a complex with factor IXa, calcium, and phospholipids.
Polypeptide reacting: Factor VIIIc protein (epitope localization: intact 83 kD light chain).
Disorders specifically detected: Elevated levels of factor VIII have been associated with acute and chronic liver diseases, vascular disorders, diabetes and with acute-phase reactions.
Reference
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