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anti-Glicentin/Glucagon rabbit polyclonal, serum

The antibody is reactive with glicentin as well as glucagon. The antibody can be used for the diagnosis of tumors from the distal intestine (rectal carcinoids) as well as pancreatic islet cell tumors.
Cat. No.: 16034
Quantity:  50 µL

Delivery Time: usually 1-7 working days

€411.00
Excl. 19% Tax, excl. Shipping Cost

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Specifications

Product description

Host rabbit
Antibody Type polyclonal
Immunogen porcine pancreatic glucagon (Novo, Denmark), conjugated to BSA
Purification undiluted antiserum
Conjugate unconjugated
Formulation lyophilized; reconstitute in 100 µl dist. water
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity hamster, human, pig, rat

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:1,000 - 1:3,000
Immunohistochemistry (IHC) - frozen 1:1,000 - 1:3,000
Immunohistochemistry (IHC) - paraffin 1:1,000 - 1:3,000 (microwave treatment recommended)

Background

Details

Glicentin contains the glucagon sequence and is produced in a prominent population of endocrine cells in the distal intestine as well as in pancreatic glucagon cells and in the nerves in the brain. Serum levels of glicentin are elevated after food uptake and in certain clinical conditions, e.g. after resections of the intestine. The functional role of glicentin is largely unknown. Glicentin occurs in endocrine tumors arising in the distal intestine (rectal carcinoids) and in pancreatic islet cell tumors.
Absorption with 10-100 µg glucagon and glicentin per ml diluted antiserum abolishes the staining, while secretin, GIP and VIP do not.

Positive control: Formalin-fixed paraffin sections of pig pancreas.

Reference

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