anti-hCG beta mouse monoclonal, 5H4-E2, purified

Cat. No. 691515

Available, delivery time 1-7 days

€340.00*

Key Features
  • Mouse monoclonal
  • Suitable for IHC
  • Reacts with human
  • Isotype: IgG1 kappa
Product description
Quantity 1 ml (100 µg/ml)
Antibody Type Monoclonal
Host Mouse
Isotype IgG1 kappa
Conjugate Unconjugated
Application IHC
Purification Affinity chromatography
Reactivity Human
Storage 2-8°C
Intended use Research use only
Clone 5H4-E2
Immunogen hCG beta, conjugated to various carrier proteins
Concentration 100 µg/ml
Formulation PBS with 0.02% sodium azide
Applications
Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:50-1:100 (1-2 µg/ml)
Immunohistochemistry (IHC) - paraffin 1:50-1:100 (1-2 µg/ml)
Background

5H4-E2 reacts with hCG beta chain, which is specific for hCG. The alpha chain is identical among hCG, TSH, FSH and LH. While hCG is secreted in large quantities by normal trophoblasts, it is present only in trace amounts in non-pregnant urine and sera, but rises sharply during pregnancy. Besides trophoblastic tumors e.g. choriocarcinoma, large cell carcinoma, adenocarcinoma and squamous cell carcinoma of the lung are also positive in 90%, 60% and 20% of cases, respectively. In hCG producing tumors, including also certain testicular and embryonic carcinomas, the beta chain is produced in higher quantities than the alpha or dimeric chains. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

Positive control: JAR or TT cells, placenta.

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