anti-human Ig lambda mouse monoclonal, 48.0, supernatant

Cat. No. 11011

Available, delivery time 1-7 days

€201.00*

Key Features
  • Mouse monoclonal
  • Suitable for ELISA, ICC/IF and IHC on frozen and paraffin sections
  • Reacts with human
  • Isotype: IgG1
Product description
Quantity 1 ml
Antibody Type Monoclonal
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Application ELISA, ICC/IF, IHC
Purification Hybridoma cell culture supernatant
Reactivity Human
Storage Short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/thaw cycles
Intended use Research use only
Clone 48
Immunogen Isolated from Bence Jones lambda proteins
Formulation Contains 0.09% sodium azide
Note Centrifuge prior to opening
Applications
Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) Assay dependent
Immunohistochemistry (IHC) - frozen 1:5-1:10
Immunohistochemistry (IHC) - paraffin 1:5-1:10 (microwave treatment recommended)
ELISA Assay dependent
Background

Suitable for characterization of malignant B-cell proliferations. All but acute lymphocytic leukemias share either surface or intra-cytoplasmic Ig with an isotypic restriction suggesting a monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenstoem's disease bear intracytoplasmic IgM. The other isotypes are found less frequently; multiple myelomas are usually of the IgG or IgA type. Also suitable for the characterization of plasma cells in intestinal inflammatory conditions, e.g. for the classification of intestinal bowel disease and allergic conditions.
In the latter case a specific increase in the number of IgE plasma cells can be demonstrated.
In ELISA the antibody reacts with lambda light chains of secreted immunoglobulins and with bound Ig on the surface of B lymphocytes.
Positive control: tonsil.

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