mouse tongue (courtesy of L. Langbein)

anti-Keratin K13 mouse monoclonal, Ks13.1, lyophilized, purified

The anti-keratin K13 Ks13.1 antibody reacts with non-cornified squamous epithelia and neoplasms derived therefrom. Protease pretreatment improves the performance of this excellent marker in immunohistochemistry.

Cat. No.: 61007
Quantity: 50 µg
No. of experiments: ≤ 200 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$251.00

Excl. VAT, excl. Shipping Cost

Qty:

Publication

Species

Application

Heid, H. W., Moll, I. & Franke, W. W. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles. Differentiation. 37, 137â57 (1988).

human

IHC (frozen)

Heid, H. W., Moll, I. & Franke, W. W. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (h

human

IHC (frozen)

Moll, R. et al. Cytokeratins in normal and malignant transitional epithelium: maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines. Am. J. Pathol. 132, 123â144 (1988).

human

WB
IHC (frozen)
ICC-IF

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Specifications

Datasheet

Alternative Products

Cat. No.	Product Name	Format	Quantity	Price
65007	anti-Keratin K13 mouse monoclonal, Ks13.1	prediluted, purified, ready-to-use	5 mL	$161.00 Excl. VAT, excl. Shipping Cost
19007	anti-Keratin K13 mouse monoclonal, Ks13.1	prediluted, purified	1 mL	$215.00 Excl. VAT, excl. Shipping Cost

Product description

Host	mouse
Antibody Type	monoclonal
Isotype	IgG1
Clone	Ks13.1
Immunogen	Keratin K13 of Mr 54 000 purified from human esophagus
Purification	protein A affinity chromatography
Conjugate	unconjugated
Formulation	lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage	short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments	≤ 200 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)
Intended use	Research use only
Tested species reactivity	bovine, human, rat

Applications

Tested applications	Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF)	assay dependent
Immunohistochemistry (IHC) - frozen	1:10
Immunohistochemistry (IHC) - paraffin	1:10 (protease treatment and/or microwave treatment recommended)
Western Blot (WB)	1:50 - 1:100

Background

Details

Ks 13.1 represents an excellent marker to discriminate non-cornified squamous epithelia from those of different origin.
Polypeptide reacting: Mr 54 000 polypeptide human keratin K13 (formerly designated cytokeratin13; with minor affinity to keratins K14, Mr 50 000, and K16, Mr 48 000 and also to K25, formerly designated K25irs1 from inner root sheath of hair follicle).
Tumors specifically detected: several squamous cell carcinomas, e.g. cervix carcinoma; transitional cell carcinoma of the bladder; craniopharyngioma
Reactivity on cultured cell lines: Cell lines from squamous cell CA, e.g. A-431 from epidermoid CA of vulva; RT 112, RT-4 of urinary bladder CA

Reference

Publication

Species

Application

Heid, H. W., Moll, I. & Franke, W. W. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles. Differentiation. 37, 137â57 (1988).

human

IHC (frozen)

human

IHC (frozen)

human

WB
IHC (frozen)
ICC-IF

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anti-Keratin K13 mouse monoclonal, Ks13.1, lyophilized, purified

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