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IHC of mouse tail (courtesy of J.Heß, University Hospital Heidelberg) Zoom

IHC of mouse tail (courtesy of J.Heß, University Hospital Heidelberg)

anti-Keratin K17 mouse monoclonal, Ks17.E3, lyophilized, purified

The antibody recognizes myoepithelial cells; benign tumors of mammary gland; malignant forms are negative.
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Cat. No.: 61036
Quantity:  50 µg

Delivery Time: usually 1-7 working days

Excl. 19% Tax, excl. Shipping Cost

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2b
Clone Ks17.E3
Immunogen human keratin K17 of 46 kDa
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity human, rat


Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:10 - 1:50
Immunohistochemistry (IHC) - paraffin 1:10 - 1:50 (microwave treatment recommended)
Western Blot (WB) assay dependent



Ks 17.E3 represents an excellent marker to distinguish myoepithelial cells (positive for K17) from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and benign from malignant forms of e.g. mammary gland tumors.
In the epidermis suprabasal staining is found only in cornifying regions and in the outer root sheath of hair follicles.
Tested reactivity on cultured cell lines: HeLa, A-431
Tumors specifically detected: Benign tumors of mammary gland; most malignant forms of mammary tumors are negative for keratin K17



Langbein, L., Yoshida, H., Praetzel-Wunder, S., Parry, D. A. & Schweizer, J. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle. J. Invest. Dermatol. 130, 55–73 (2010). human IHC (frozen)
Langbein, L. et al. Characterization of a Novel Human Type II Epithelial Keratin K1b, Specifically Expressed in Eccrine Sweat Glands. J. Invest. Dermatol. 125, 428–444 (2005). human IHC (frozen)
Moll, I. et al. Human Merkel cells--aspects of cell biology, distribution and functions. Eur. J. Cell Biol. 84, 259–71 (2005). human IHC (paraffin)
Romih, R., Jezernik, K. & Masera, A. Uroplakins and cytokeratins in the regenerating rat urothelium after sodium saccharin treatment. Histochem. Cell Biol. 109, 263–9 (1998). rat IHC (paraffin)
Demirkesen, C., Hoede, N. & Moll, R. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J. Cutan. Pathol. 22, 518–35 (1995). human IHC (paraffin)
Möbus, V. J. et al. Establishment of new ovarian and colon carcinoma cell lines: differentiation is only possible by cytokeratin analysis. Br. J. Cancer 69, 422–428 (1994). human ICC-IF
Moll, R. et al. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation. 53, 75–93 (1993). human IHC (frozen)
Smedts, F. et al. Keratin Expression in Cervical Cancer. Am. J. Pathol. 141, 497–511 (1992). human IHC (frozen)
Smedts, F. et al. Basal-cell Keratins in Cervical Reserve Cells and a Comparison to Their Expression in Cervical Intraepithelial Neoplasia. Am. J. Pathol. 140, (1992). human WB, IHC (frozen)
Wetzels, R. H. et al. Laminin and type VII collagen distribution in different types of human lung carcinoma: correlation with expression of keratins 14, 16, 17 and 18. Histopathology 20, 295–303 (1992). human IHC (frozen)
Wetzels, R. H. W. et al. Basal Cell-specific and Hyperproliferation-related Keratins in Human Breast Cancer. Am. J. Pathol. 138, 751–763 (1991). human IHC (frozen)
de Jong, E. M. et al. Keratin 17: a useful marker in anti-psoriatic therapies. Arch. Dermatol. Res. 283, 480–2 (1991). human IHC (frozen)
Moll, I. & Moll, R. Comparative cytokeratin analysis of sweat gland ducts and eccrine poromas. Arch. Dermatol. Res. 283, 300–9 (1991). human IHC (frozen)
Troyanovsky, S. M., Guelstein, V. I., Tchipysheva, T. A., Krutovskikh, V. A. & Bannikov, G. A. Patterns of expression of keratin 17 in human epithelia: dependency on cell position. J. Cell Sci. 93, 419–26 (1989). human WB, IHC (frozen), ICC-IF
Guelstein, V. I. et al. Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int. J. cancer 42, 147–53 (1988). human WB, IHC (frozen)

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