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Alternative Products
| Cat. No. | Product Name | Format | Quantity | Price |
|---|---|---|---|---|
| 61054 |
anti-Keratin K20 mouse monoclonal, IT-Ks20.10 |
lyophilized, purified | 50 µg |
$371.00
Excl. VAT, excl. Shipping Cost
|
| 65054 |
anti-Keratin K20 mouse monoclonal, IT-Ks20.10 |
prediluted, purified | 5 mL |
$225.00
Excl. VAT, excl. Shipping Cost
|
Product description
| Host | mouse |
|---|---|
| Antibody Type | monoclonal |
| Isotype | IgG1 |
| Clone | IT-Ks20.10 |
| Immunogen | electrophoretically purified keratin K 20 from human intestinal mucosa |
| Purification | affinity chromatography |
| Conjugate | FITC |
| Formulation | contains 0.09% sodium azide and 0.5% BSA |
| Storage | store at 2-8°C |
| No. of experiments | ≤ 100 (IHC, 50 µl/slide) |
| Note | centrifuge prior to opening |
| Intended use | Research use only |
| Tested species reactivity | human, mouse, pig |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunocytochemistry (ICC)/ Immunofluorescence (IF) | assay dependent |
| Immunohistochemistry (IHC) - frozen | 1:10 – 1:20 |
| Immunohistochemistry (IHC) - paraffin | 1:10 – 1:20 (microwave treatment recommended) |
Background
Details
IT-Ks 20.10 represents an excellent marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin. Very sensitive detection of intestestinal and gastric foveolar epithelium, urothelial umbrella cells, Merkel cells of epidermis as well as tumors originating therefrom (e.g. primary and metastatic colorectal carcinoma). Adenocarcinomas of breast, lung, endometrium and ovary (non-mucinous) as well as neuroendocrine tumors of the lung are essentially negative.
Polypeptide recognized: protein IT (keratin K20; Mr 46 000; formerly also designated cytokeratin 20).
Reactivity on cultured cell lines: HT-29, LoVo, DLD-1, SW 1116, CaCo-2, RT-4
Reference
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