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  • anti-Keratin K6 mouse monoclonal, KA12, lyophilized, purified

human skin (courtesy of J.Heß, University Hospital Heidelberg) Zoom

human skin (courtesy of J.Heß, University Hospital Heidelberg)

anti-Keratin K6 mouse monoclonal, KA12, lyophilized, purified

Excellent marker for non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions).
highly_published external_validation
Cat. No.: 61090
Quantity:  50 µg

Delivery Time: usually 1-7 working days

$251.00
Excl. 19% Tax, excl. Shipping Cost

Filter

Publication
Species
Application
Boink, M. et al. Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials. J.Tissue.Eng.Regen.Med. 12, e1088-e1097 (2018).
human
IHC (paraffin)
Kist, R. et al. The Formation of Endoderm-Derived Taste Sensory Organs Requires a Pax9-Dependent Expansion of Embryonic Taste Bud Progenitor Cells. PLoS Genet. 10, (2014).
mouse
IHC (frozen)
Wallace, L., Roberts-Thompson, L. & Reichelt, J. Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. J. Cell Sci. 125, 1750–1758 (2012).
mouse
IHC (frozen)
Langbein, L., Yoshida, H., Praetzel-Wunder, S., Parry, D. A. & Schweizer, J. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle. J. Invest. Dermatol. 130, 55–73 (2010).
human
IHC (frozen)
Langbein, L., Eckhart, L., Rogers, M. A., Praetzel-Wunder, S. & Schweizer, J. Against the rules: Human keratin K80 - Two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia. J. Biol. Chem.
human
IHC (frozen)
Langbein, L. et al. Characterization of a Novel Human Type II Epithelial Keratin K1b, Specifically Expressed in Eccrine Sweat Glands. J. Invest. Dermatol. 125, 428–444 (2005).
human
IHC (frozen)
Herrmann, T. et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J. Cell Biol. 161, 1105–1115 (2003).
mouse
IHC (paraffin)
Langbein, L., Rogers, M. A., Praetzel, S., Winter, H. & Schweizer, J. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J. Invest. Dermatol. 120, 512–522 (2003).
human
WB
Langbein, L. et al. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle. J. Invest. Dermatol. 118, 789–799 (2002).
human
WB
Demirkesen, C., Hoede, N. & Moll, R. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J. Cutan. Pathol. 22, 518–35 (1995).
human
IHC (paraffin)
Smedts, F. et al. Keratin expression in cervical cancer. Am. J. Pathol. 141, 497–511 (1992).
human
IHC (frozen)
Wetzels, R. H. W. et al. Basal Cell-specific and Hyperproliferation-related Keratins in Human Breast Cancer. Am. J. Pathol. 138, 751–763 (1991).
human
IHC (frozen)

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Cat. No. Product Name Format Quantity Price
19090

anti-Keratin K6 mouse monoclonal, KA12

 prediluted, purified 1 mL
$248.00
Excl. 19% Tax, excl. Shipping Cost

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone Ks6.KA12
Immunogen Keratin K6 of human callus cytoskeletal preparation
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
UniprotID P02538
Intended use Research use only
Tested species reactivity human, mouse, rat

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:5 - 1:50
Immunohistochemistry (IHC) - paraffin 1:5 - 1:50 (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

Ks6.KA12 represents an excellent marker for non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions).

Polypeptide reacting: Mr 56 000 polypeptide (keratin K6; formerly also designated cytokeratin 6) of human squamous epithelia.

Tissues and Tumors specifically detected: The antibody is suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma.

Reference

Filter

Publication
Species
Application
Boink, M. et al. Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials. J.Tissue.Eng.Regen.Med. 12, e1088-e1097 (2018).
human
IHC (paraffin)
Kist, R. et al. The Formation of Endoderm-Derived Taste Sensory Organs Requires a Pax9-Dependent Expansion of Embryonic Taste Bud Progenitor Cells. PLoS Genet. 10, (2014).
mouse
IHC (frozen)
Wallace, L., Roberts-Thompson, L. & Reichelt, J. Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. J. Cell Sci. 125, 1750–1758 (2012).
mouse
IHC (frozen)
Langbein, L., Yoshida, H., Praetzel-Wunder, S., Parry, D. A. & Schweizer, J. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle. J. Invest. Dermatol. 130, 55–73 (2010).
human
IHC (frozen)
Langbein, L., Eckhart, L., Rogers, M. A., Praetzel-Wunder, S. & Schweizer, J. Against the rules: Human keratin K80 - Two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia. J. Biol. Chem.
human
IHC (frozen)
Langbein, L. et al. Characterization of a Novel Human Type II Epithelial Keratin K1b, Specifically Expressed in Eccrine Sweat Glands. J. Invest. Dermatol. 125, 428–444 (2005).
human
IHC (frozen)
Herrmann, T. et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J. Cell Biol. 161, 1105–1115 (2003).
mouse
IHC (paraffin)
Langbein, L., Rogers, M. A., Praetzel, S., Winter, H. & Schweizer, J. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J. Invest. Dermatol. 120, 512–522 (2003).
human
WB
Langbein, L. et al. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle. J. Invest. Dermatol. 118, 789–799 (2002).
human
WB
Demirkesen, C., Hoede, N. & Moll, R. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. J. Cutan. Pathol. 22, 518–35 (1995).
human
IHC (paraffin)
Smedts, F. et al. Keratin expression in cervical cancer. Am. J. Pathol. 141, 497–511 (1992).
human
IHC (frozen)
Wetzels, R. H. W. et al. Basal Cell-specific and Hyperproliferation-related Keratins in Human Breast Cancer. Am. J. Pathol. 138, 751–763 (1991).
human
IHC (frozen)

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