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human tongue (courtesy of L. Langbein) Zoom

human tongue (courtesy of L. Langbein)

anti-Keratin K80 guinea pig polyclonal, serum

K80 is found in virtually all types of epithelia (stratified keratinizing-/ non-keratinizing-, hard-keratinizing- as well as non-stratified tissues, and cell cultures thereof). Throughout, K80 expression is related to advanced tissue or cell differentiation. However, instead of being part of the cytoplasmic IF network, K80 containing IFs are located at the cell margins close to the desmosomal plaques, where they are tightly interlaced with the cytoplasmic IF bundles abutting there. In contrast, in cells entering terminal differentiation, K80 adopts the "conventional" cytoplasmic distribution. In addition, KRT80 mRNA is subject to alternative splicing resulting in fully functional splice variant K80.1.
Cat. No.: GP-K80
Quantity:  100 µl
No. of experiments:  ≤ 1000 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

$311.00
Excl. VAT, excl. Shipping Cost

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Specifications

Product description

Host guinea pig
Antibody Type polyclonal
Immunogen synthetic peptide from human K80: IKI TEM SEK YFS QE-C
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 1000 (IHC, 50 µl/slide)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity human, mouse

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:500
Western Blot (WB) assay dependent

Background

Details

K80 is found in virtually all types of epithelia (stratified keratinizing-/ non-keratinizing-, hard-keratinizing- as well as non-stratified tissues, and cell cultures thereof). Throughout, K80 expression is related to advanced tissue or cell differentiation. However, instead of being part of the cytoplasmic IF network, K80 containing IFs are located at the cell margins close to the desmosomal plaques, where they are tightly interlaced with the cytoplasmic IF bundles abutting there. In contrast, in cells entering terminal differentiation, K80 adopts the "conventional" cytoplasmic distribution. In addition, KRT80 mRNA is subject to alternative splicing resulting in fully functional splice variant K80.1.

Reference

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