IHC of human HNSCC tissue (courtesy of J.Heß, University Hospital Heidelberg)

anti-Keratin Type II mouse monoclonal, Ks pan1-8, lyophilized, purified

The antibody detects all epithelia and epithelium-derived neoplasms.

Cat. No.: 61006
Quantity: 50 µg
No. of experiments: ≤ 2000 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

$251.00

Excl. VAT, excl. Shipping Cost

Qty:

Publication

Species

Application

Kimelman, D. et al. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Elife. 6,Â (2017).

zebrafish

whole mount

Hatzold, J. et al. Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.eLife, 5 (2016).

zebrafish

whole mount

Fischer, B. et al. p53 and TAp63 Promote Keratinocyte Proliferation and Differentiation in Breeding Tubercles of the Zebrafish 6 Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases. PLoS Genet 10, (2014).

zebrafish

IHC

Montpetit, A. et al. Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord. PLoS Genet 4, (2008).

zebrafish

whole mount

AchtstÃ¤tter, T., Fouquet, B., RunggerâBraUndele, E. & Frnake, W. W. Cytokeratin filaments and desmonsomes in the epithelioid cells of the perineurial and arachnoidal sheaths of some vertebrate species. Differentiation 40, 129â149 (1989).

human
xenopus

WB
IHC (frozen)

Rungger-Brandle, E., Achtstatter, T. & Franke, W. W. An epithelium-type cytoskeleton in a glial cell: Astrocytes of amphibian optic nerves contain cytokeratin filaments and are connected by desmosomes. J. Cell Biol. 109, 705â716 (1989).

xenopus

WB
IHC (frozen)
IEM

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Specifications

Datasheet

Product description

Host	mouse
Antibody Type	monoclonal
Isotype	IgG2a
Clone	Ks pan1-8
Immunogen	cytoskeletal proteins from cultured human MCF-7 cells
Purification	protein A affinity chromatography
Conjugate	unconjugated
Formulation	lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage	short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments	≤ 2000 (IHC, 50 µl/slide)
Intended use	Research use only
Tested species reactivity	amphibia, bovine, human, mouse, rat

Applications

Tested applications	Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF)	assay dependent
Immunohistochemistry (IHC) - frozen	1:10 - 1:100
Immunohistochemistry (IHC) - paraffin	1:10 - 1:100 (microwave treatment recommended)
Western Blot (WB)	assay dependent

Background

Details

Ks pan1-8 represents an excellent marker for distinguishing carcinomas from non-epithelial tumors.
Polypeptides reacting: Mr 52 500 - Mr 68 000 keratins (type II keratins K1 - K8; formerly also designated cytokeratins 1 - 8) of human epithelial cells.
Tumors specifically detected: all epithelium-derived neoplasms.

Reactivity on cultured cell lines MCF-7, RT 112, HT-29, Detroit 562, RPMI 2650, SSC-12.

Reference

Publication

Species

Application

Kimelman, D. et al. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Elife. 6,Â (2017).

zebrafish

whole mount

Hatzold, J. et al. Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.eLife, 5 (2016).

zebrafish

whole mount

zebrafish

IHC

Montpetit, A. et al. Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord. PLoS Genet 4, (2008).

zebrafish

whole mount

human
xenopus

WB
IHC (frozen)

xenopus

WB
IHC (frozen)
IEM

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anti-Keratin Type II mouse monoclonal, Ks pan1-8, lyophilized, purified

Product description

Applications

Background

Details

Reference

Material safety data sheet

Please complete the form below to request a material safety data sheet

Personal Info

Product Request

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anti-Keratin Type II mouse monoclonal, Ks pan1-8, lyophilized, purified

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