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anti-Lamin A + C mouse monoclonal, R27, supernatant

The monoclonal antibody decorates the caryoskeleton, i.e. the intermediate filament equivalent to the nucleus. Specific reaction with lamin type A and C.
Cat. No.: 651138
Quantity:  5 mL

Delivery Time: usually 1-7 working days

€196.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgM
Clone R27
Immunogen Nuclear pore complex-lamina fraction of bovine liver
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity bovine, human, mouse, trout, xenopus, zebrafish

Applications

Immunocytochemistry (ICC)/ Immunofluorescence (IF) ready-to-use
Western Blot (WB) assay dependent

Background

Details

The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope.
Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in human and mouse and other laminopathies (for review see Burke & Stewart, 2002).

Polypeptides reacting: Lamin isotypes A and C (Mr 60 - 75 kD); meiotic lamin C2

Reactivity in cultured cell lines: RV-SMC (rat vascular smooth muscle cells)

Antigen recognized in species:

Xenopus laevis      LA
human LA, C
bovine LA, C
mouse LA, C
rat LA, C
trout LA
zebrafish LA

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