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Product description
| Host | mouse |
|---|---|
| Antibody Type | monoclonal |
| Isotype | IgM |
| Clone | R27 |
| Immunogen | Nuclear pore complex-lamina fraction of bovine liver |
| Purification | hybridoma cell culture supernatant |
| Conjugate | unconjugated |
| Formulation | contains 0.09% sodium azide |
| Storage | short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles |
| Intended use | Research use only |
| Tested species reactivity | bovine, human, mouse, trout, xenopus, zebrafish |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunocytochemistry (ICC)/ Immunofluorescence (IF) | ready-to-use |
| Western Blot (WB) | assay dependent |
Background
Details
The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope.
Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in human and mouse and other laminopathies (for review see Burke & Stewart, 2002).
Polypeptides reacting: Lamin isotypes A and C (Mr 60 - 75 kD); meiotic lamin C2
Reactivity in cultured cell lines: RV-SMC (rat vascular smooth muscle cells)
Antigen recognized in species:
| Xenopus laevis | LA |
| human | LA, C |
| bovine | LA, C |
| mouse | LA, C |
| rat | LA, C |
| trout | LA |
| zebrafish | LA |
Reference
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