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anti-LRP1 (85kD) mouse monoclonal, 8B8, lyophilized w/o sodium azide, purified

The antibody recognizes human 85 kD LRP light chain. Cross-reacts with rabbit LDL receptor-related protein (LRP) or mouse LRP.
Cat. No.: 61067
Quantity:  50 µg
No. of experiments:  ≤ 400 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

$293.00
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Specifications

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone 8B8
Immunogen human LRP/alpha-2MR
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 400 (IHC, 50 µl/slide)
Intended use Research use only
Tested species reactivity hamster, human, mouse, rabbit, rat

Applications

Tested applications Tested dilutions
Flow Cytometry (FACS) assay dependent
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen 1:20
Immunohistochemistry (IHC) - paraffin 1:20 (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

8B8 specifically reacts with the 85 kD beta-chain of human LRP/alpha-2MR which is expressed in a restricted spectrum of cell types (Herz & Strickland 2001). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).

Herz J and Strickland DK: LRP, a multifunctional scavanger and signaling receptor. J. Clin. Invest. 108, 779-784 (2001)

Reference

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