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anti-MSH2 mouse monoclonal, IHC410, purified

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly
associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with
the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high
percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of
Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports
have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic
tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.
Cat. No.: 691741
Quantity:  1 mL
No. of experiments:  ≤ 4000 (IHC, 50 µl/slide)

Delivery Time: usually 5-10 working days

$588.00
Excl. VAT, excl. Shipping Cost

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Specifications

Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2b
Clone IHC410
Immunogen Recombinant Human MSH2
Purification affinity chromatography
Conjugate unconjugated
Formulation Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide
Storage store at 2-8°C
No. of experiments ≤ 4000 (IHC, 50 µl/slide)
Intended use Research use only
Tested species reactivity human

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - paraffin 1:50-1:200 (microwave treatment recommended)

Background

Details

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.

Reference

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