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anti-Organic Anion Transporter OATP2 mouse monoclonal, mESL, supernatant

The anti-Organic Anion Transporter OATP2 monoclonal antibody to human hepatic organic anion transporter SLC21A6 (OATP2, also known as OATP1B1 and OATP-C) detects the antigens upregulated in hepatocellular carcinoma.
Mouse monoclonal anti-Organic Anion Transporter OATP2 antibody.
Cat. No.: 651139
Quantity:  5 mL

Delivery Time: usually 1-7 working days

€196.00
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Product description

Host mouse
Antibody Type monoclonal
Isotype IgM
Clone mESL
Immunogen synthetic C-terminus (21 aa) of human organic anion transporter SLC21A6 coupled to KLH
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity human
Intended use Research use only

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen ready-to-use
Immunohistochemistry (IHC) - paraffin ready-to-use (microwave treatment recommended)
Immunoprecipitation (IP) assay dependent
Western Blot (WB) assay dependent (for optimal detection of the glycosylated antigen sample boiling before SDS-PAGE is not recommended; alternatively, samples should be kept at 37°C for 30 min)

Background

Details

In Western blot analyses the monoclonal antibody mESL reacts selectively with the 90 kD protein (after SDS-PAGE) present in the basolateral membrane fractions of human liver. According to a recent new nomenclature this hepatocyte-specific protein is identical to OATP1B1 (Hagenbuch and Meier, 2003) also known as OATP-C.
Using immunofluorescence microscopy mESL stains the sinusoidal (basolateral) membranes in frozen sections of human liver, hepatocellular carcinoma and the human cell line HEK293 transfected with SLC21A6.

Polypeptide reacting: OATP2/OATP1B1, human organic anion transporter SLC21A6 (90 kD).

Reactivity on cultured cell lines: SCL21A6 transfected HEK293 cells; negative with HepG2 and PLC.

Hagenbuch E, Meier PJ: The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609, 1-18 (2003)

Reference

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