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anti-p16 Protein mouse monoclonal, DCS-50, supernatant

p16, a protein implicated in cancer, is a specific inhibitor for Cdk4 and Cdk6. It binds to phosphorylated Cdk-cyclin complex which is recognized by DCS-50.
Cat. No.: 65174
Quantity:  5 mL
No. of experiments:  ≤ 100 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

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anti-p16 Protein mouse monoclonal, DCS-50

lyophilized, purified 50 µg
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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone DCS-50
Immunogen recombinant p16 protein
Purification hybridoma cell culture supernatant
Conjugate unconjugated
Formulation contains 0.09% sodium azide
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
UniprotID P42771
No. of experiments ≤ 100 (IHC, 50 µl/slide)
Intended use Research use only
Tested species reactivity human


Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen ready-to-use
Immunohistochemistry (IHC) - paraffin ready-to-use (microwave treatment recommended)
Western Blot (WB) assay dependent



p16 (CDKN2A, p16Ink4A), is key regulator of the cell cycle and involved in cell cycle control and cellular senescence. It is a specific inhibitor for Cdk4 and Cdk6 and binds to the phosphorylated Cdk-cyclin complex. A disruption of this pathway is commonly observed in cancer. p16 is lost in the majority of tumor cell lines and in most primary tumors. It is not expressed in melanoma. In carcinoma driven by an HPV (human papilloma virus) infection, p16 is often overexpressed. The antibody is especially useful for immunoprecipitation. The epitope was localized within the 15 aa residues of the C-terminus of p16 protein.


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