anti-p504s mouse monoclonal, IHC504, purified
- Mouse monoclonal
- Suitable for IHC
- Reacts with human
- Isotype: IgG1
|Intended use||Research use only|
|Immunogen||Recombinant Human p504s|
|Formulation||Tris pH 7.3-7.7 with 1% BSA and 0.09% sodium azide|
|Synonym||Alpha-methylacyl-CoA racemase, EC 184.108.40.206, 2-methylacyl-CoA racemase, AMACR
|Tested applications||Tested dilutions|
|Immunohistochemistry (IHC) - paraffin||1:50-1:200 (microwave treatment recommended)|
p504s, also known as α-Methylacyl Coenzyme A Racemase (AMACR), is an enzyme localized in the peroxisome and mitochondria that functions in β-oxidation of branched chain fatty acids, as well as bile synthesis. AMACR has been clinically indicated as a tissue biomarker for prostate cancer and colorectal cancer, as well as high-grade prostatic intraepithelial neoplasia, a precursor lesion of prostate cancer. p504s overexpression has also been detected in a number of other cancers including ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma.
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