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  • anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

human colon (courtesy of J.Heß, University Hospital Heidelberg) Zoom

human colon (courtesy of J.Heß, University Hospital Heidelberg)

anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

The anti-p62 antibody is useful for research in ubiquitin-associated degradation and autophagy and for detection of neurofibrillary tangles in the brain of Alzheimer disease patients, in Parkinson diseases and various chronic liver diseases. Human p62 protein, present in intracytoplasmic inclusions is found in many tissues and cells, serving probably a common cellular signal transduction mechanism.
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Cat. No.: GP62-C
Quantity:  100 µL

Delivery Time: usually 1-7 working days

$343.00
Excl. 19% Tax, excl. Shipping Cost

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Publication
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Application
Matta, S. et al. NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages. MBio. 9,  (2018).
mouse
ICC-IF
Kageyama, S. et al. Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. Mol.Cell.Biol. ,  (2018).
mouse
WB
Alam, S. et al. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. J.Am.Heart.Assoc. 7,  (2018).
mouse
WB
Barutcu, S. et al. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 14, 1586-1595 (2018).
mouse
WB
Sebori, R. et al. Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice. Oxid.Med.Cell.Longev. 2018, 9179270 (2018).
mouse
WB
Aron, R. et al. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat.Commun. 9, 3191 (2018).
rat
WB
Takahashi, M. et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 9, 433-450 (2018).
human
WB
ICC-IF
Ogmundsdóttir, M. et al. A short isoform of ATG7 fails to lipidate LC3/GABARAP. Sci.Rep. 8, 14391 (2018).
mouse
WB
McLelland, G. et al. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife. 7,  (2018).
human
WB
Kuno, A. et al. Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice. Sci.Rep. 8, 15555 (2018).
mouse
WB
Nikam, A. et al. The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity. Sci.Rep. 8, 12964 (2018).
mouse
WB
Vincent, A. et al. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann.Neurol. 84, 289-301 (2018).
human
IHC-IF (frozen)
Lim, H. et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat.Commun. 9, 1438 (2018).
human
WB
Nwadike, C. et al. AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Mol.Cell.Biol. 38,  (2018).
mouse
ICC
Battista, R. et al. Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation. PLoS.One. 13, e0201621 (2018).
human
WB
ICC-IF
Oehl, K. et al. Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression. Front.Oncol. 8, 40 (2018).
human
WB
Liu, S. et al. Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis. Cell.Death.Dis. 9, 476 (2018).
mouse
IHC (frozen)
Carroll, B. et al. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat.Commun. 9, 256 (2018).
human
mouse
WB
Sebastiani, A. et al. Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front.Neurosci. 11, 678 (2018).
mouse
WB
Mitsui, S. et al. Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model. Mol.Brain. 11, 30 (2018).
mouse
IHC-IF (paraffin)
Koyuncu, S. et al. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat.Commun. 9, 2886 (2018).
human
WB
Hartupee, J. et al. Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Circ.Heart.Fail. 10,  (2017).
mouse
IHC-IF (paraffin)
Yanagisawa, H. et al. L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human N324ann-Pick type C disease. Sci.Rep. 7, 15944 (2017).
human
WB
Sample, A. et al. Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J.Biol.Chem. 292, 14786-14795 (2017).
human
WB
Vargas, T. et al. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells. Nat.Commun. 8, 559 (2017).
mouse
WB
Fung, G. et al. Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis. Oncotarget. 8, 74767-74780 (2017).
mouse
rat
WB
Gallagher, L. et al. Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell.Death.Dis. 8, e3014 (2017).
mouse
WB
Nascimbeni, A. et al. Local detection of PtdIns3P at autophagosome biogenesis membrane platforms. Autophagy. 13, 1602-1612 (2017).
human
WB
Conte, A. et al. High mobility group A1 protein modulates autophagy in cancer cells. Cell.Death.Differ. 24, 1948-1962 (2017).
human
ICC-IF
Mishra, P. et al. Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Autophagy. 13, 1556-1572 (2017).
mouse
WB
ICC-IF
McLendon, P. et al. An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circ.Res. 121, 604-616 (2017).
rat
WB
Feldmann, A. et al. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem. Biophys. Res. Commun. 486, 738–743 (2017).
human
WB
IHC (frozen)
Fajardo, V. A. et al. Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. PLoS One 12, e0173708 (2017).
mouse
WB
Aas, A. et al. Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy. PLoS One 12, e0168182 (2017).
mouse
WB
Ruf, S. et al. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 13, 486–505 (2017).
human
ICC-IF
Nascimbeni, A. C., Fanin, M., Angelini, C. & Sandri, M. Autophagy dysregulation in Danon disease. Cell Death Dis. 8, e2565 (2017).
human
WB
IHC (frozen)
Lee, M. Y. et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 18, 48–60 (2017).
mouse
WB
Sergin, I. et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat. Commun. 8, 15750 (2017).
human
mouse
WB
IHC (frozen)
ICC-IF
Joachim, J. et al. Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy. Curr. Biol. 27, 2123–2136.e7 (2017).
human
ICC-IF
Jacquier, A. et al. Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death. Acta Neuropathol. Commun. 5, 55 (2017).
human
chicken
IHC (frozen)
ICC-IF
Mildenberger, J. et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy 00–00 (2017).
human
mouse
WB
ICC-IF
Duleh, S., Wang, X., Komirenko, A. & Margeta, M. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol. Commun. 4, 115 (2016).
human
mouse
WB
IHC (frozen)
Santanam, U. et al. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 30, 399–407 (2016).
mouse
WB
Sergin, I. et al. p62-enriched inclusion bodies in macrophages protect against atherosclerosis HHS Public Access. Sci. Signal. 9, (2016).
mouse
IHC (frozen)
ICC-IF
Starheim, K. et al. Intracellular glutathione determines borte. cytotoxicity in multiple myeloma cells. Blood Cancer J. 6, (2016).
human
WB
Yamanaka, T. et al. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Nat. Publ. Gr. 6, (2016).
mouse
WB
IHC (frozen)
Lim, S. W., Jin, L., Jin, J. & Yang, C. W. Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. Nat. Publ. Gr. 6, (2016).
rat
WB
IHC (paraffin)
Angelini, C., Nascimbeni, A. C., Cenacchi, G. & Tasca, E. Lipolysis and lipophagy in lipid storage myopathies. Biochim. Biophys. Acta 1367–1373 (2016).
human
WB
IHC (frozen)
Corcelle-Termeau, E. et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy 12, 533–849 (2016)
mouse
WB
Ra, E. A. et al. TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. Nat. Commun. 7, (2016).
human
WB
Kaizuka, T. & Mizushima, N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol. Cell. Biol. 36, 585–595 (2016).
mouse
WB
ICC-IF
Saito, T. et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat. Commun. 7, (2016).
human
mouse
WB
IHC (paraffin)
Jarvela, T. S. et al. The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. (2016).
human
IHC (frozen)
Puvirajesinghe, T. M. et al. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer. Nat. Commun. 7, (2016).
human
mouse
WB
ICC-IF
Salas, E., Roy, S., Marsh, T., Rubin, B. & Debnath, J. Oxidative Pentose Phosphate Pathway Inhibition Is A Key Determinant of Antimalarial Induced Cancer Cell Death. Oncogene 35, 2913–2922 (2016).
mouse
ICC-IF
Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1 (2016).
mouse
WB
Zhang, J. et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 12,(2016).
human
WB
Kenific, C. M. et al. NBR1 enables autophagy-dependent focal adhesion turnover. J. Cell Biol. 212, 577–90 (2016).
human
WB
Taneike, M. et al. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. PLoS One 11, (2016).
mouse
WB
Morimoto, D. et al. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat. Commun. 6, (2015).
mouse
WB
ICC-IF
Echeverry, N. et al. Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell Death Dis. 6, (2015).
human
WB
Milan, E. et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy 11, 1161–1178 (2015).
human
WB
ICC-IF
Lenoir, O. et al. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy 11, 1130–45 (2015).
mouse
WB
Larroquette, F. et al. Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response. Hum. Mol. Genet. 24, 6515–6529 (2015).
mouse
WB
Hieke, N. et al. Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells. Autophagy 11, 1471–1483 (2015).
mouse
WB
ICC-IF
Zhou, Z. et al. Autophagy supports color vision. Autophagy 11, 1821–1832 (2015).
mouse
IHC (frozen)
Ciuffa, R. et al. The selective autophagy receptor p62 forms a flexible filamentous helical scaffold. Cell Rep. 11, 748–58 (2015).
human
WB
Ulbricht, A. et al. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle. Autophagy 11, 538–546 (2015).
human
WB
Murrow, L., Malhotra, R. & Debnath, J. ATG12-ATG3 Interacts with Alix to Promote Basal Autophagic Flux and Late Endosome Function. Nat. Cell Biol. 17, 300–310 (2015).
mouse
WB
Lim, J. et al. Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates. PLoS One 11, (2015).
human
mouse
WB
ICC-IF
Pellegrini, C. et al. All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Oncotarget 6, 29914–29928 (2015).
human
WB
Eino, A. et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J. Cell Sci. 128, 4453–61 (2015).
mouse
IHC (paraffin)
Felzen, V. et al. Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. Cell Death Dis. 6, (2015).
human
ICC-IF
Chandrachud, U. et al. Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca 2+ Homeostasis, Autophagy, and CLN3 Protein Function. J. Biol. Chem. 290, 14361–14380 (2015).
mouse
WB
Liu, S. et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 6, (2015).
rat
WB
IHC (frozen)
McMillan, E. M. et al. Autophagic signaling and proteolytic enzyme activity in cardiac and skeletal muscle of spontaneously hypertensive rats following chronic aerobic exercise. PLoS One 10, e0119382 (2015).
rat
WB
Johansson, I. et al. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy 11, 1636–1651 (2015).
human
mouse
WB
ICC-IF
Lodder, J. et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy 11, 1280–1292 (2015).
mouse
ICC-IF
Agarwal, S. et al. Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol- 3-phosphate-specific phospholipase A1 activity. Nat. Commun. 6, (2015).
human
WB
Akizu, N. et al. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction HHS Public Access. Nat. Genet. 47, 528–534 (2015).
human
WB
Ruozi, G. et al. AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia. Nat. Commun. 6, (2015).
mouse
WB
Arel-Dubeau, A.-M. et al. Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons. Oxid. Med. Cell. Longev. 2014, 15 (2015).
rat
WB
Clayton, E. L. et al. Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology. Acta Neuropathol. 130, 511–23 (2015).
mouse
IHC (paraffin)
IEM
Newton, P. T., Vuppalapati, K. K., Bouderlique, T. & Chagin, A. S. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner. Autophagy 11, 1594–1607 (2015).
mouse
rat
WB
Shi, J. et al. NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1. Cell Death Dis. 6, (2015).
human
WB
Khan, M. M. et al. Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors. Autophagy 10, 123–36 (2014).
mouse
WB
IHC
Costes, S., Gurlo, T., Rivera, J. F. & Butler, P. C. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy 10, 1004–14 (2014).
mouse
WB
IHC (paraffin)
Karlsson, A. B. et al. The role of spartin and its novel ubiquitin binding region in DALIS occurrence. Mol. Biol. Cell 25, 1355–1365 (2014).
mouse
ICC-IF
Dunlop, E. A. et al. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10, 1749–1760 (2014).
human
mouse
WB
IHC
Nicot, A.-S. et al. Phosphorylation of NBR1 by GSK3 modulates protein aggregation. Autophagy 10, 1036–53 (2014).
human
WB
Rivera, J. F., Costes, S., Gurlo, T., Glabe, C. G. & Butler, P. C. Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity. J. Clin. Invest. 124, 3489–500 (2014).
mouse
WB
IHC (paraffin)
Kinsey, C. et al. Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. Cell Rep. 7, 1143–1155 (2014).
human
mouse
WB
Sahani, M. H., Itakura, E. & Mizushima, N. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy 10, 431–41 (2014).
mouse
WB
ICC-IF
Guan, B.-J. et al. Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2␣ *. J. Biol. Chem. 289, 12593–12611 (2014).
mouse
WB
Lim, Y.-M. et al. Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat. Commun. 5, (2014).
mouse
WB
Ricketts, T. et al. A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. PLoS One 9, (2014).
mouse
IHC (paraffin)
Kondratskyi, A. et al. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death. Cell Death Dis. 5, (2014).
human
WB
Tanaka, K. et al. A Novel Acylaminoimidazole Derivative, WN1316, Alleviates Disease Progression via Suppression of Glial Inflammation in ALS Mouse Model. PLoS One 9, (2014).
mouse
WB
Heijnen, H. F. et al. Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway. PLoS Genet. 10, (2014).
human
WB
ICC-IF
Ost, M., Werner, F., Dokas, J., Klaus, S. & Voigt, A. Activation of AMPKa2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity. PLoS One 9, (2014).
mouse
WB
Zatloukal, B. et al. Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with mallory-denk bodies. PLoS One 9, (2014).
mouse
IHC (frozen)
Sarkar, C. et al. Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. Autophagy 10, 2208–2222 (2014).
mouse
IHC (frozen)
Cottam, E. M., Whelband, M. C. & Wileman, T. Coronavirus NSP6 restricts autophagosome expansion. Autophagy 10, (2014).
monkey
WB
ICC-IF
Gabandé-Rodrıuez, E., Boya, P., Labrador, V., Dotti, C. & Ledesma, M. High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in N324ann Pick disease type A. Cell Death Differ. 21, 864–875 (2014).
mouse
WB
Xu, X. et al. Autophagy is essential for effector CD8 T cell survival and memory formation. Nat. Immunol. 15, 1152–1161 (2014).
mouse
WB
Furuya, N. et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy 10, 631–41 (2014).
mouse
WB
Zhang, L. et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat. Commun. 5, (2014).
mouse
WB
IHC (paraffin)
ICC-IF
IP
Yamanaka, T. et al. NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat. Commun. 5, (2014).
mouse
WB
IHC (frozen)
IEM
Kageyama, S. et al. Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway. J. Biol. Chem. 289, 24944–24955 (2014).
mouse
WB
IHC (frozen)
Yamano, K. & Youle, R. J. PINK1 is degraded through the N-end rule pathway. Autophagy 9, 1758–69 (2013).
human
ICC-IF
Kondylis, V. et al. Endosome-mediated autophagy: an unconventional MIIC-driven autophagic pathway operational in dendritic cells. Autophagy 9, 861–80 (2013).
mouse
WB
ICC-IF
IEM
Yuan, H.-X., Russell, R. C. & Guan, K.-L. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 9, 1983–95 (2013).