Call +49 6221 8278-0

PROGEN - passion for research

close×
  • Home
  • anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

human colon (courtesy of J.Heß, University Hospital Heidelberg) Zoom

human colon (courtesy of J.Heß, University Hospital Heidelberg)

anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

The anti-p62 antibody is useful for research in ubiquitin-associated degradation and autophagy and for detection of neurofibrillary tangles in the brain of Alzheimer disease patients, in Parkinson diseases and various chronic liver diseases. Human p62 protein, present in intracytoplasmic inclusions is found in many tissues and cells, serving probably a common cellular signal transduction mechanism.
application_confirmed highly_published external_validation
Cat. No.: GP62-C
Quantity:  100 µL
No. of experiments:  ≤ 600 (IHC, 50 µl/slide); ≤ 3000 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$343.00
Excl. VAT, excl. Shipping Cost

Filter

Publication
Species
Application
Takahashi, S. et al. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life.Sci.Alliance. 3, (2020)
mouse
WB
Aghajan, M. et al. Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice. JCI.Insight. 4, (2019)
mouse
WB
Anisimov, S. et al. G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Sci.Rep. 9, 12896 (2019)
human
WB
Birgisdottir, Å. et al. Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy. , Jan-23 (2019)
human
WB
IHC
IP
Gurlo, T. et al. Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 62, 1000-1010 (2019)
mouse
IHC-IF (paraffin)
Hill, C. et al. Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell.Death.Dis. 10, 591 (2019)
human
IHC (paraffin)
Horigome, Y. et al. Loss of autophagy in chondrocytes causes severe growth retardation. Autophagy. , 1-11 (2019)
mouse
IHC (paraffin)
Jung, S. et al. Buffering of cytosolic calcium plays a neuroprotective role by preserving the autophagy-lysosome pathway during MPP+-induced neuronal death. Cell.Death.Discov. 5, 130 (2019)
mouse
WB
Kessler, S. et al. Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. PLoS.One. 14, e0214756 (2019)
pig
IHC (paraffin)
Li, Y. et al. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury. Cell.Death.Dis. 10, 531 (2019)
mouse
IHC (frozen)
Lim, J. et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins. Elife. 8, (2019)
mouse
WB
Pasquier, A. et al. Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes. Nat.Commun. 10, 3312 (2019)
mouse
ICC-IF
Pellegrini, C. et al. Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Exp.Mol.Med. 51, 89 (2019)
human
WB
ICC-IF
Rienzo, M. et al. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. Sci.Adv. 5, eaau8857 (2019)
mouse
IHC-IF (paraffin)
Sarkar, C. et al. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. , 1-20 (2019)
mouse
ICC
Sarraf, S. et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell.Rep. 29, 225-235.e5 (2019)
mouse
WB
Schwob, A. et al. SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function. Sci.Rep. 9, 16014 (2019)
human
IF
WB
Tamura, N. et al. Hyperosmotic stress induces unconventional autophagy independent of the Ulk1 complex. Mol.Cell.Biol. , (2019)
human
mouse
WB
ICC
Wang, Y. et al. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. , Jan-14 (2019)
mouse
ICC-IF
WB
Yang, S. et al. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat.Commun. 10, 2782 (2019)
human
WB
Yang, Y. et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat.Commun. 10, 3759 (2019)
human
WB
Castets, P. et al. mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nat.Commun. 10, 3187 (2019)
mouse
IHC (paraffin)
Klimek, C. et al. The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim. Biophys. Acta - Mol. Cell Res. 1866, 1556–1566 (2019).
human
WB
Matta, S. et al. NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages. MBio. 9,  (2018).
mouse
ICC-IF
Kageyama, S. et al. Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. Mol.Cell.Biol. ,  (2018).
mouse
WB
Alam, S. et al. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. J.Am.Heart.Assoc. 7,  (2018).
mouse
WB
Barutcu, S. et al. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 14, 1586-1595 (2018).
mouse
WB
Sebori, R. et al. Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice. Oxid.Med.Cell.Longev. 2018, 9179270 (2018).
mouse
WB
Aron, R. et al. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat.Commun. 9, 3191 (2018).
rat
WB
Takahashi, M. et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 9, 433-450 (2018).
human
WB
ICC-IF
Ogmundsdóttir, M. et al. A short isoform of ATG7 fails to lipidate LC3/GABARAP. Sci.Rep. 8, 14391 (2018).
mouse
WB
McLelland, G. et al. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife. 7,  (2018).
human
WB
Kuno, A. et al. Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice. Sci.Rep. 8, 15555 (2018).
mouse
WB
Nikam, A. et al. The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity. Sci.Rep. 8, 12964 (2018).
mouse
WB
Vincent, A. et al. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann.Neurol. 84, 289-301 (2018).
human
IHC-IF (frozen)
Lim, H. et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat.Commun. 9, 1438 (2018).
human
WB
Nwadike, C. et al. AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Mol.Cell.Biol. 38,  (2018).
mouse
ICC
Battista, R. et al. Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation. PLoS.One. 13, e0201621 (2018).
human
WB
ICC-IF
Oehl, K. et al. Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression. Front.Oncol. 8, 40 (2018).
human
WB
Liu, S. et al. Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis. Cell.Death.Dis. 9, 476 (2018).
mouse
IHC (frozen)
Carroll, B. et al. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat.Commun. 9, 256 (2018).
human
mouse
WB
Sebastiani, A. et al. Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front.Neurosci. 11, 678 (2018).
mouse
WB
Mitsui, S. et al. Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model. Mol.Brain. 11, 30 (2018).
mouse
IHC-IF (paraffin)
Koyuncu, S. et al. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat.Commun. 9, 2886 (2018).
human
WB
Cabe, M. et al. PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation. Biochem.Biophys.Res.Commun. 503, 2306-2311 (2018)
mouse
WB
Furuya, N. et al. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. EMBO.Rep. 19, (2018)
human
WB
Livingston, J. et al. Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients. Mol.Cancer.Ther. 17, 1315-1323 (2018)
human
IHC (paraffin)
Mauthe, M. et al. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 14, 1435-1455 (2018)
human
ICC-IF
Mejlvang, J. et al. Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy. J.Cell.Biol. 217, 3640-3655 (2018)
human
WB
ICC-IF
Miret-Casals, L. et al. Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism. Cell.Chem.Biol. 25, 268-278.e4 (2018)
human
WB
Prabakaran, T. et al. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. EMBO.J. 37, (2018)
human
mouse
WB
ICC-IF
Wang, L. et al. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell.Res. 28, 787-802 (2018)
human
ICC-IF
Ziegler, P. et al. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 174, 88-101.e16 (2018)
human
IHC-IF (paraffin)
Hartupee, J. et al. Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Circ.Heart.Fail. 10,  (2017).
mouse
IHC-IF (paraffin)
Yanagisawa, H. et al. L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human N324ann-Pick type C disease. Sci.Rep. 7, 15944 (2017).
human
WB
Sample, A. et al. Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J.Biol.Chem. 292, 14786-14795 (2017).
human
WB
Vargas, T. et al. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells. Nat.Commun. 8, 559 (2017).
mouse
WB
Fung, G. et al. Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis. Oncotarget. 8, 74767-74780 (2017).
mouse
rat
WB
Gallagher, L. et al. Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell.Death.Dis. 8, e3014 (2017).
mouse
WB
Nascimbeni, A. et al. Local detection of PtdIns3P at autophagosome biogenesis membrane platforms. Autophagy. 13, 1602-1612 (2017).
human
WB
Conte, A. et al. High mobility group A1 protein modulates autophagy in cancer cells. Cell.Death.Differ. 24, 1948-1962 (2017).
human
ICC-IF
Mishra, P. et al. Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms. Autophagy. 13, 1556-1572 (2017).
mouse
WB
ICC-IF
McLendon, P. et al. An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circ.Res. 121, 604-616 (2017).
rat
WB
Feldmann, A. et al. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem. Biophys. Res. Commun. 486, 738–743 (2017).
human
WB
IHC (frozen)
Fajardo, V. A. et al. Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. PLoS One 12, e0173708 (2017).
mouse
WB
Aas, A. et al. Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy. PLoS One 12, e0168182 (2017).
mouse
WB
Ruf, S. et al. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 13, 486–505 (2017).
human
ICC-IF
Nascimbeni, A. C., Fanin, M., Angelini, C. & Sandri, M. Autophagy dysregulation in Danon disease. Cell Death Dis. 8, e2565 (2017).
human
WB
IHC (frozen)
Lee, M. Y. et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 18, 48–60 (2017).
mouse
WB
Sergin, I. et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat. Commun. 8, 15750 (2017).
human
mouse
WB
IHC (frozen)
ICC-IF
Joachim, J. et al. Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy. Curr. Biol. 27, 2123–2136.e7 (2017).
human
ICC-IF
Jacquier, A. et al. Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death. Acta Neuropathol. Commun. 5, 55 (2017).
human
chicken
IHC (frozen)
ICC-IF
Mildenberger, J. et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy 00–00 (2017).
mouse
WB
Bartolomeo, R. et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J.Clin.Invest. 127, 3717-3729 (2017)
mouse
IHC-IF (frozen)
Giaime, E. et al. Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. Neuron. 96, 796-807.e6 (2017)
mouse
WB
Michel, C. et al. Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation. J.Immunol. 199, 3488-3503 (2017)
human
mouse
IHC-IF (frozen)
Shiba-Fukushima, K. et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum.Mol.Genet. 26, 3172-3185 (2017)
human
WB
Wallot-Hieke, N. et al. Systematic analysis of ATG13 domain requirements for autophagy induction. Autophagy. , 1-58 (2017)
mouse
ICC-IF
Duleh, S., Wang, X., Komirenko, A. & Margeta, M. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol. Commun. 4, 115 (2016).
human
mouse
WB
IHC (frozen)
Santanam, U. et al. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 30, 399–407 (2016).
mouse
WB
Sergin, I. et al. p62-enriched inclusion bodies in macrophages protect against atherosclerosis HHS Public Access. Sci. Signal. 9, (2016).
mouse
IHC (frozen)
ICC-IF
Starheim, K. et al. Intracellular glutathione determines borte. cytotoxicity in multiple myeloma cells. Blood Cancer J. 6, (2016).
human
WB
Yamanaka, T. et al. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Nat. Publ. Gr. 6, (2016).
mouse
WB
IHC (frozen)
Lim, S. W., Jin, L., Jin, J. & Yang, C. W. Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. Nat. Publ. Gr. 6, (2016).
rat
WB
IHC (paraffin)
Angelini, C., Nascimbeni, A. C., Cenacchi, G. & Tasca, E. Lipolysis and lipophagy in lipid storage myopathies. Biochim. Biophys. Acta 1367–1373 (2016).
human
WB
IHC (frozen)
Corcelle-Termeau, E. et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy 12, 533–849 (2016)
mouse
WB
Ra, E. A. et al. TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. Nat. Commun. 7, (2016).
human
WB
Kaizuka, T. & Mizushima, N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol. Cell. Biol. 36, 585–595 (2016).
mouse
WB
ICC-IF
Saito, T. et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat. Commun. 7, (2016).
human
mouse
WB
IHC (paraffin)
Jarvela, T. S. et al. The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. (2016).
human
IHC (frozen)
Puvirajesinghe, T. M. et al. Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer. Nat. Commun. 7, (2016).
human
mouse
WB
ICC-IF
Salas, E., Roy, S., Marsh, T., Rubin, B. & Debnath, J. Oxidative Pentose Phosphate Pathway Inhibition Is A Key Determinant of Antimalarial Induced Cancer Cell Death. Oncogene 35, 2913–2922 (2016).
mouse
ICC-IF
Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1 (2016).
mouse
WB
Zhang, J. et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 12,(2016).
human
WB
Kenific, C. M. et al. NBR1 enables autophagy-dependent focal adhesion turnover. J. Cell Biol. 212, 577–90 (2016).
human
WB
Taneike, M. et al. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. PLoS One 11, (2016).
mouse
WB
Morimoto, D. et al. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat. Commun. 6, (2015).
mouse
WB
ICC-IF
Echeverry, N. et al. Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell Death Dis. 6, (2015).
human
WB
Milan, E. et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy 11, 1161–1178 (2015).
human
WB
ICC-IF
Lenoir, O. et al. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy 11, 1130–45 (2015).
mouse
WB