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  • anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

human colon (courtesy of J.Heß, University Hospital Heidelberg) Zoom

human colon (courtesy of J.Heß, University Hospital Heidelberg)

anti-p62 / SQSTM1 (C-terminus) guinea pig polyclonal, serum

The anti-p62 antibody is useful for research in ubiquitin-associated degradation and autophagy and for detection of neurofibrillary tangles in the brain of Alzheimer disease patients, in Parkinson diseases and various chronic liver diseases. Human p62 protein, present in intracytoplasmic inclusions is found in many tissues and cells, serving probably a common cellular signal transduction mechanism.
application_confirmed highly_published external_validation
Cat. No.: GP62-C
Quantity:  100 µL
No. of experiments:  ≤ 600 (IHC, 50 µl/slide); ≤ 3000 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$343.00
Excl. VAT, excl. Shipping Cost

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Publication
Species
Application
Takahashi, S. et al. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life.Sci.Alliance. 3, (2020)
mouse
WB
Choi, I. et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat.Commun. 11, 1386 (2020)
mouse
ICC-IF
Deng, Z. et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 16, 917-931 (2020)
human
mouse
WB
Leidal, A. et al. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat.Cell.Biol. 22, 187-199 (2020)
human
WB
Jakobi, A. et al. Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake. Nat.Commun. 11, 440 (2020)
human
WB
Dohmen, M. et al. AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy. Nat.Commun. 11, 1032 (2020)
mouse
WB
Kakimoto, Y. et al. Myocardial cathepsin D is downregulated in sudden cardiac death. PLoS.One. 15, e0230375 (2020)
human
WB
Noman, M. et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci.Adv. 6, eaax7881 (2020)
mouse
WB
Kurashige, T. et al. Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice. J.Endocr.Soc. 4, bvaa054 (2020)
rat
WB
IHC-IF (paraffin)
Aghajan, M. et al. Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice. JCI.Insight. 4, (2019)
mouse
WB
Anisimov, S. et al. G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Sci.Rep. 9, 12896 (2019)
human
WB
Birgisdottir, Å. et al. Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy. , Jan-23 (2019)
human
WB
IHC
IP
Carballo-Carbajal, I. et al. Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis. Nat.Commun. 10, 973 (2019)
rat
WB
IHC (paraffin)
Chakraborty, D. et al. Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox.Biol. 24, 101181 (2019)
mouse
WB
Garcia, D. et al. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell.Rep. 26, 192-208.e6 (2019)
mouse
WB
Gorgulu, K. et al. Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Gastroenterology. 156, 203-217.e20 (2019)
mouse
WB
Gurlo, T. et al. Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 62, 1000-1010 (2019)
mouse
IHC-IF (paraffin)
Hill, C. et al. Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell.Death.Dis. 10, 591 (2019)
human
IHC (paraffin)
Horigome, Y. et al. Loss of autophagy in chondrocytes causes severe growth retardation. Autophagy. , 1-11 (2019)
mouse
IHC (paraffin)
Igawa, H. et al. p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes. J.Diabetes.Investig. 10, 32-42 (2019)
mouse
WB
Jung, S. et al. Buffering of cytosolic calcium plays a neuroprotective role by preserving the autophagy-lysosome pathway during MPP+-induced neuronal death. Cell.Death.Discov. 5, 130 (2019)
mouse
WB
Kessler, S. et al. Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs. PLoS.One. 14, e0214756 (2019)
pig
IHC (paraffin)
Kim, W. et al. Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia. Sci.Rep. 9, 3021 (2019)
mouse
IHC (paraffin)
Li, Y. et al. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury. Cell.Death.Dis. 10, 531 (2019)
mouse
IHC (frozen)
Lim, J. et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins. Elife. 8, (2019)
mouse
WB
Olivé, M. et al. Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions. Nat.Commun. 10, 1396 (2019)
human
IHC (frozen)
Pasquier, A. et al. Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes. Nat.Commun. 10, 3312 (2019)
mouse
ICC-IF
Pellegrini, C. et al. Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Exp.Mol.Med. 51, 89 (2019)
human
WB
ICC-IF
Pigna, E. et al. Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis. EBioMedicine. 40, 717-732 (2019)
mouse
IHC-IF (frozen)
Rienzo, M. et al. Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. Sci.Adv. 5, eaau8857 (2019)
mouse
IHC-IF (paraffin)
Saito, T. et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat.Commun. 10, 1567 (2019)
mouse
WB
Sarkar, C. et al. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. , 1-20 (2019)
mouse
ICC
Sarraf, S. et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell.Rep. 29, 225-235.e5 (2019)
mouse
WB
Schwob, A. et al. SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function. Sci.Rep. 9, 16014 (2019)
human
IF
WB
Tamura, N. et al. Hyperosmotic stress induces unconventional autophagy independent of the Ulk1 complex. Mol.Cell.Biol. , (2019)
human
mouse
WB
ICC
Wang, Y. et al. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. , Jan-14 (2019)
mouse
ICC-IF
WB
Yang, S. et al. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat.Commun. 10, 2782 (2019)
human
WB
Yang, Y. et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat.Commun. 10, 3759 (2019)
human
WB
Castets, P. et al. mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4. Nat.Commun. 10, 3187 (2019)
mouse
IHC (paraffin)
Bonsi, P. et al. RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models. EMBO.Mol.Med. 11, (2019)
mouse
WB
Klimek, C. et al. The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim. Biophys. Acta - Mol. Cell Res. 1866, 1556–1566 (2019).
human
WB
Hoem, G. et al. The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS. Front.Genet. 10, 249 (2019)
human
ICC-IF
Ma, X. et al. Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. J.Am.Heart.Assoc. 8, e010866 (2019)
mouse
IHC (paraffin)
Lachance, V. et al. Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice. Mol.Neurodegener. 14, 43 (2019)
mouse
WB
Suzuki, C. et al. Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions. Int.J.Mol.Sci. 21, (2019)
mouse
ICC-IF
Gasset-Rosa, F. et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 102, 339-357.e7 (2019)
human
ICC-IF
Aubert, P. et al. Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring. FASEB.J. 33, 770-781 (2019)
rat
WB
Glatigny, M. et al. Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline. Curr.Biol. 29, 435-448.e8 (2019)
mouse
WB
IHC-IF (frozen)
Nam, S. et al. Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway. Cell.Death.Dis. 10, 78 (2019)
mouse
WB
IHC (paraffin)
Park, S. et al. A lysosomal chloride ion-selective fluorescent probe for biological applications. Chem.Sci. 10, 56-66 (2019)
human
ICC-IF
Kinsey, C. et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat.Med. 25, 620-627 (2019)
mouse
IHC (paraffin)
Zhang, J. et al. Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency. Autophagy. , 1-19 (2019)
mouse
WB
Sánchez-López, E. et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell.Metab. 29, 1350-1362.e7 (2019)
mouse
ICC
Sánchez-López, E. et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell.Metab. 29, 1350-1362.e7 (2019)
mouse
ICC
Sabino, C. et al. Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection. Viruses. 11, (2019)
human
WB
Liang, S. et al. Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J.Biol.Chem. , (2019)
mouse
WB
Riemschoss, K. et al. Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells. Life.Sci.Alliance. 2, (2019)
mouse
WB
ICC-IF
Vanzo, R. et al. Autophagy role(s) in response to oncogenes and DNA replication stress. Cell.Death.Differ. , (2019)
human
WB
Himuro, M. et al. Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture. J.Endocr.Soc. 3, 1979-1992 (2019)
mouse
IHC (paraffin)
Javaheri, A. et al. TFEB activation in macrophages attenuates postmyocardial infarction ventricular dysfunction independently of ATG5-mediated autophagy. JCI.Insight. 4, (2019)
human
IHC (paraffin)
Tang, T. et al. Dihydroartemisinin and its anticancer activity against endometrial carcinoma and cervical cancer: involvement of apoptosis, autophagy and transferrin receptor. Singapore.Med.J. , (2019)
human
WB
Overå, K. et al. TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1. J.Cell.Sci. 132, (2019)
human
WB
Matta, S. et al. NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages. MBio. 9,  (2018).
mouse
ICC-IF
Kageyama, S. et al. Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant. Mol.Cell.Biol. ,  (2018).
mouse
WB
Alam, S. et al. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. J.Am.Heart.Assoc. 7,  (2018).
mouse
WB
Barutcu, S. et al. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 14, 1586-1595 (2018).
mouse
WB
Sebori, R. et al. Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice. Oxid.Med.Cell.Longev. 2018, 9179270 (2018).
mouse
WB
Aron, R. et al. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat.Commun. 9, 3191 (2018).
rat
WB
Takahashi, M. et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 9, 433-450 (2018).
human
WB
ICC-IF
Ogmundsdóttir, M. et al. A short isoform of ATG7 fails to lipidate LC3/GABARAP. Sci.Rep. 8, 14391 (2018).
mouse
WB
McLelland, G. et al. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife. 7,  (2018).
human
WB
Kuno, A. et al. Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice. Sci.Rep. 8, 15555 (2018).
mouse
WB
Nikam, A. et al. The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity. Sci.Rep. 8, 12964 (2018).
mouse
WB
Vincent, A. et al. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann.Neurol. 84, 289-301 (2018).
human
IHC-IF (frozen)
Lim, H. et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat.Commun. 9, 1438 (2018).
human
WB
Nwadike, C. et al. AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Mol.Cell.Biol. 38,  (2018).
mouse
ICC
Battista, R. et al. Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation. PLoS.One. 13, e0201621 (2018).
human
WB
ICC-IF
Oehl, K. et al. Live-Cell Mesothelioma Biobank to Explore Mechanisms of Tumor Progression. Front.Oncol. 8, 40 (2018).
human
WB
Liu, S. et al. Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis. Cell.Death.Dis. 9, 476 (2018).
mouse
IHC (frozen)
Carroll, B. et al. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat.Commun. 9, 256 (2018).
human
mouse
WB
Sebastiani, A. et al. Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice. Front.Neurosci. 11, 678 (2018).
mouse
WB
Mitsui, S. et al. Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model. Mol.Brain. 11, 30 (2018).
mouse
IHC-IF (paraffin)
Koyuncu, S. et al. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat.Commun. 9, 2886 (2018).
human
WB
Cabe, M. et al. PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation. Biochem.Biophys.Res.Commun. 503, 2306-2311 (2018)
mouse
WB
Fernández, A. et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 558, 136-140 (2018)
mouse
WB
Furuya, N. et al. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. EMBO.Rep. 19, (2018)
human
WB
Livingston, J. et al. Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients. Mol.Cancer.Ther. 17, 1315-1323 (2018)
human
IHC (paraffin)
Mauthe, M. et al. Chloroquine inhibits autophagic flux by decreasing autophagosom