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human skin (courtesy of J.Heß, University Hospital Heidelberg)

anti-Perilipin 2 (N-terminus aa 1-29) guinea pig polyclonal, serum

Specific marker for liposarcoma. Adipophilin/Perilipin 2 is present in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir. Detected in the glandular cells of lactating mammary gland, adrenal gland, Sertoli cells, in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; In CD68-positive macrophages. Adipocytes are negative.
highly_published external_validation
Cat. No.: GP40
Quantity:  100 µL
No. of experiments:  ≤ 500 (IHC, 50 µl/slide); ≤ 40 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$356.00
Excl. VAT, excl. Shipping Cost

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Specifications

Alternative Products

Cat. No. Product Name Format Quantity Price
GP40S

anti-Perilipin 2 (N-terminus aa 1-29) guinea pig polyclonal

serum, sample (ready-to-use) 600 µL (ready-to-use)
$65.00
Excl. VAT, excl. Shipping Cost
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anti-Perilipin 1-5 complete sample set

600 µl each antibody
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Product description

Host guinea pig
Antibody Type polyclonal
Immunogen synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin)
Purification stabilized antiserum
Conjugate unconjugated
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 500 (IHC, 50 µl/slide); ≤ 40 (WB, 5 ml reaction volume)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity human, mouse (predicted: rat, dog, bovine)

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - paraffin 1:100 - 1:250 (microwave treatment recommended)
Western Blot (WB) 1:2,000

Background

Details

Perilipin 2/ Adipophilin/ ADRP/ PLIN2 (a member of the PLIN/PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir.
Enhanced expression of Perilipin 2/ Adipophilin/ ADRP/ PLIN2 is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis.
ADRP can also be used to study the virus entry via lipid droplets.
Polypeptide reacting: Specific for Perilipin 2/ Adipophilin/ ADRP/ PLIN2, MW 48,100 (calculated from aa sequence data); apparent Mr 52,000 (after SDS-PAGE); pI 6.72
Immunolocalization: Adipophilin/ PLIN2 is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculata of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative.
Also positively stained are lipid-storing CD 68-positive macrophages.

Learn more about PROGEN Perilipin antibodies.

Reference

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