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anti-Perilipin 2 (N-terminus aa 6-27) guinea pig polyclonal, serum

Specific marker for liposarcoma. Adipophilin/Perilipin 2 is present in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir. Detected in the glandular cells of lactating mammary gland, adrenal gland, Sertoli cells, in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; In CD68-positive macrophages. Adipocytes are negative. The antibody recognizes N-terminal aa 6-27 of human adipophilin 2 (PLIN2).
Cat. No.: GP47
Quantity:  100 µL

Delivery Time: usually 1-7 working days

€266.00
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Product description

Host guinea pig
Antibody Type polyclonal
Immunogen Synthetic peptide (N-terminal aa 6-27 of human adipophilin / PLIN2)
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity human, mouse

Applications

Immunohistochemistry (IHC) - frozen 1:100
Immunohistochemistry (IHC) - paraffin 1:100 (microwave treatment recommended)
Western Blot (WB) 1:2000

Background

Details

Adipophilin / ADRP / PLIN2 is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al. 1998; for review see e.g. Targett-Adams et al.); inducible by etomoxir. Enhanced expression of Adipophilin / ADRP / PLIN2 is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis. ADRP can also be used to study the virus entry of e.g. HCV via lipid droplets (see e.g. Hope et al.). Polypeptide reacting: Adipophilin / ADRP / PLIN2, MW 48,100 (calculated from aa sequence data); apparent Mr 52,000 (after SDS-PAGE); pI 6.72

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