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IHC of rat colon (courtesy of J.Heß, University Hospital Heidelberg) Zoom

IHC of rat colon (courtesy of J.Heß, University Hospital Heidelberg)

anti-Perilipin 2 (N-terminus) mouse monoclonal, AP125, purified, sample (ready-to-use)

Positive in glandular cells of lactating mammary gland, zona fasciculata of the adrenal gland, Sertoli cells, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative. Specific detection of liposarcoma.
highly_published external_validation
Cat. No.: 610102S
Quantity:  600 µL (ready-to-use)
No. of experiments:  ≤ 12 (IHC, 50 µl/slide)

Delivery Time: usually 1-7 working days

$65.00
Excl. VAT, excl. Shipping Cost

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Specifications

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone AP125
Immunogen synthetic peptide (aa 5-27 from N-terminus of human adipophilin/ PLIN2)
Purification affinity chromatography
Conjugate unconjugated
Formulation contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 12 (IHC, 50 µl/slide)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity dog, human, rat (negative with bovine)

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen ready-to-use
Immunohistochemistry (IHC) - paraffin ready-to-use (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

Perilipin 2/ Adipophilin/ ADRP/ PLIN2 is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines; inducible by etomoxir.
Enhanced expression of Perilipin 2/ Adipophilin/ ADRP/ PLIN2 is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis. ADRP can also be used to study virus entry via lipid droplets.
Polypeptide reacting: Perilipin 2/ Adipophilin/ ADRP/ PLIN2, MW 48,100 (calculated from aa sequence data); apparent Mr 52,000 (after SDS-PAGE); pI 6.72
Immunolocalization: Perilipin 2/ Adipophilin/ ADRP/ PLIN2 is positively detected in the glandular cells of lactating mammary gland (ductal cells are negative), zona fasciculata of the adrenal gland, Sertoli cells of the testis, and in fat-accumulating hepatocytes of alcoholic cirrhotic fatty liver; adipocytes are negative.Also positively stained are lipid-storing CD 68-positive macrophages.
Tested cultured cell lines: PLC, MDCK

Learn more about PROGEN Perilipin antibodies.

Reference

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