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anti-Perilipin 3 (C-terminus) guinea pig polyclonal, serum

Cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Also localized in the milk fat globule membranes. Increased amounts are found in cervix carcinoma patients.
Cat. No.: GP32
Quantity:  100 µL
No. of experiments:  ≤ 400 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$333.00
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Specifications

Product description

Host guinea pig
Antibody Type polyclonal
Immunogen synthetic peptide of TIP47 C-terminus (hCTA/B; aa 420 - 431); C-terminal epitope
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
No. of experiments ≤ 400 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity human

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:100 – 1:200
Immunohistochemistry (IHC) - paraffin 1:100 – 1:200 (microwave treatment recommended)
Western Blot (WB) 1:1,000

Background

Details

TIP47 (tail-interacting protein of 47 kD; also named PLIN3) is involved in lipid droplet maturation (Bulankina et al. 2009). The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. After radical surgery TIP47 serum levels are decreased (Than et al. 1999).

TIP47 shows about 40% sequence homology to adipophilin (PLIN2). The GP32 antiserum, however, is specific for TIP47 (PLIN3) and does not cross-react with adipophilin (PLIN2) and perilipin (PLIN1) or other closely related members of the PLIN/PAT-family.

Learn more about PROGEN Perilipin antibodies.

Bulankina, A. V et al. TIP47 functions in the biogenesis of lipid droplets. J. Cell Biol. 185, 641–55 (2009).
Than, N. G., Sumegi, B., Than, G. N., Kispal, G. & Bohn, H. Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med. 20, 184–92 (1999).

Reference

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