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human skin (courtesy of J.Heß, University Hospital Heidelberg) Zoom

human skin (courtesy of J.Heß, University Hospital Heidelberg)

anti-Perilipin 3 (N-terminus) guinea pig polyclonal, serum

Cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Localized on the surface of lipid droplets present in many cells and tissues, especially in the milk fat globule membranes of human and bovine. Increased amounts are found in cervix carcinoma patients.
highly_published external_validation
Cat. No.: GP30
Quantity:  100 µL
No. of experiments:  ≤ 500 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)

Delivery Time: usually 1-7 working days

$293.00
Excl. VAT, excl. Shipping Cost

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Specifications

Alternative Products

Cat. No. Product Name Format Quantity Price
GP30S

anti-Perilipin 3 (N-terminus) guinea pig polyclonal

serum, sample (ready-to-use) 600 µL (ready-to-use)
$65.00
Excl. VAT, excl. Shipping Cost
70010

anti-Perilipin 1-5 complete sample set

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Product description

Host guinea pig
Antibody Type polyclonal
Immunogen synthetic peptide of TIP47 N-terminus (aa 1 – 16)
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles
UniprotID O60664
No. of experiments ≤ 500 (IHC, 50 µl/slide); ≤ 20 (WB, 5 ml reaction volume)
Note centrifuge prior to opening
Intended use Research use only
Tested species reactivity bovine, human, mouse, rat

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:100 – 1:250
Immunohistochemistry (IHC) - paraffin 1:100 – 1:250 (microwave treatment recommended)
Western Blot (WB) 1:1,000

Background

Details

TIP47 (tail-interacting protein of 47 kD; also named PLIN3) is involved in lipid droplet maturation. The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. After radical surgery TIP47 serum levels are decreased (Than et al. 1999). TIP47 shows about 40% sequence homology to adipophilin (PLIN2). The GP30 antiserum, however, is specific for TIP47 (PLIN3) and does not cross-react with adipophilin (PLIN2) and perilipin (PLIN1) or other proteins of the PLIN/PAT family. Reactivity on cultured cell lines: PLC cells, pretreated with oleic acid.

Learn more about PROGEN Perilipin antibodies.

Than, N. G., Sumegi, B., Than, G. N., Kispal, G. & Bohn, H. Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med. 20, 184–92 (1999).

Reference

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