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anti-Plakoglobin mouse monoclonal, PG 5.1, lyophilized, purified

PG 5.1 represents an excellent marker for all forms of intercellular adhering junctions.The PG 5.1 epitope maps within the C-terminus at the extreme end of repeat 13 (aa 632-687) of plakoglobin [identical to gamma-catenin].
Cat. No.: 61005
Quantity:  50 µg

Delivery Time: usually 1-7 working days

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG2b
Clone PG 5.1
Immunogen Plakoglobin, "band 5" protein from bovine snout epidermis
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4)
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity bovine, chicken, human, mouse, rat, zebrafish


Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) 1:5
Immunohistochemistry (IHC) - frozen assay dependent
Immunoprecipitation (IP) assay dependent
Western Blot (WB) assay dependent



PG 5.1 represents an excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis). The PG 5.1 epitope maps within the C-terminus at the extreme end of repeat 13 (aa 632-687) of plakoglobin. Polypeptide reacting: Mr 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (identical to γ-catenin)

Reactivity on cultured cell lines: Cell cultures forming monolayers



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  2. Fabritz, L. et al. Load-Reducing Therapy Prevents Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Plakoglobin-Deficient Mice. J. Am. Coll. Cardiol. 57, 740–750 (2011).
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  9. Cerdà, J., Reidenbach, S., Prätzel, S. & Franke, W. W. Cadherin-catenin complexes during zebrafish oogenesis: heterotypic junctions between oocytes and follicle cells. Biol. Reprod. 61, 692–704 (1999).
  10. Luft, F. C. Wingless armadillos and their clinical relevance. J. Mol. Med. (Berl). 75, 1–2 (1997).
  11. Wahl, J. K. et al. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. J. Cell Sci. 109, 1143–54 (1996).
  12. Chitaev, N. A. et al. The Binding of Plakoglobin to Desmosomal Cadherins: Patterns of Binding Sites and Topogenic Potential. J. Cell Biol. 113, 359–369 (1996).
  13. Koch, P. J. et al. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur. J. Cell Biol. 53, 1–12 (1990).
  14. Cowin, P., Kapprell, H. P., Franke, W. W., Tamkun, J. & Hynes, R. O. Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell 46, 1063–73 (1986).

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