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human oesophagus (courtesy of L. Langbein) Zoom

human oesophagus (courtesy of L. Langbein)

anti-Plakophilin 1 guinea pig polyclonal, serum

PP1 antiserum shows distinct suprabasal staining of stratified epithelia, localizing plakophilin 1 in desmosomal plaques and in the nucleus.
Cat. No.: GP-PP1
Quantity:  100 µL

Delivery Time: usually 1-7 working days

€260.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Host guinea pig
Antibody Type polyclonal
Immunogen Human recombinant plakophilin 1
Purification stabilized antiserum
Conjugate unconjugated
Formulation contains 0.09% sodium azide and 0.5% BSA
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity bovine, human, mouse, Xenopus laevis

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:100
Western Blot (WB) 1:1,000

Background

Details

PP1 antiserum shows distinct suprabasal staining of stratified epithelia, localizing plakophilin 1 in desmosomal plaques and in the nucleus. In Western blot analysis the antiserum reacts specifically with the 80kD plakophilin 1a and 1b polypeptides.

Reactivity on cultured cell lines: BPH-1 (derived from non-neoplastic prostatic tissue).

Reference

Reference

Schmidt A, Langbein L, Rode M, Praetzel S, Zimbelmann R, Franke WW: Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tiss Res 290, 481-499 (1997)

 Yang C, Fischer-Kešo R, Schlechter T, Ströbel P, Marx A, Hofmann I: Plakophilin 1-deficient cells upregulate SPOCK1: implications for prostate cancer progression. Tumor Biol. (2015) DOI 10.1007/s13277-015-3628-3

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