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anti-Substance P (aa 4-11) rabbit polyclonal, serum

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It is commonly found in midgut carcinoids.
Cat. No.: 16070
Quantity:  50 µL

Delivery Time: usually 1-7 working days

€199.00
Excl. 19% Tax, excl. Shipping Cost

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Product description

Host rabbit
Antibody Type polyclonal
Immunogen synthetic Substance P 4-11, conjugated to thyroglobulin using CDI
Purification undiluted antiserum
Conjugate unconjugated
Formulation lyophilized; reconstitute in 100 µl dist. water
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Tested species reactivity human, rat

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen 1:400 - 1:800
Immunohistochemistry (IHC) - paraffin 1:400 - 1:800 (microwave treatment recommended)

Background

Details

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, broncho-constriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Absorption with 10 – 100 µg SP 1-4 per ml diluted antiserum abolishes the staining.

Positive control: Frozen sections of rat colon.

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