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Product description
| Host | guinea pig |
|---|---|
| Antibody Type | polyclonal |
| Immunogen | synthetic human VIP (Peninsula, #7161) |
| Purification | undiluted antiserum |
| Conjugate | unconjugated |
| Formulation | lyophilized; reconstitute in 100 µl dist. water |
| Storage | short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles |
| Intended use | Research use only |
| Tested species reactivity | cat, guinea pig, human, pig, rabbit, rat |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunohistochemistry (IHC) - frozen | 1:1,000 - 1:2,000 |
| Immunohistochemistry (IHC) - paraffin | 1:1,000 - 1:2,000 (microwave treatment recommended) |
Background
Details
VIP is localized in nerve fibers of the central and peripheral nervous system, and is probably acting as a neurotransmitter. Smooth muscle relaxation, vasodilation and secretion from exocrine glands are some of the effects of VIP. The Verner-Morrison or Watery Diarrhea Hypokaliemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors. These VIP-producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.
Absorption with 10-100 µg immunogen per ml diluted antiserum abolishes the staining, while PHI does not.
Positive control: Stefanini-fixed frozen sections of rat intestine
Reference
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Publication
Species
Application
G. morhua
IHC (frozen)
whole mount
whole mount
